Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave
Introduction: The objectives of this retrospective study were to describe clinical presentations and mortality outcomes of hospitalised patients with the COVID-19 Omicron variant within two acute district general hospitals, and to evaluate demographic factors associated with these presentations and...
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European Medical Journal
2022-11-01
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| Series: | European Medical Journal |
| Online Access: | https://www.emjreviews.com/microbiology-infectious-diseases/article/demographic-and-clinical-presentation-of-hospitalised-patients-with-sars-cov-2-during-the-first-omicron-wave |
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| author | Mehool Patel Elizabeth Aitken |
| author_facet | Mehool Patel Elizabeth Aitken |
| author_sort | Mehool Patel |
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Introduction: The objectives of this retrospective study were to describe clinical presentations and mortality outcomes of hospitalised patients with the COVID-19 Omicron variant within two acute district general hospitals, and to evaluate demographic factors associated with these presentations and mortality. Methods: Data was obtained over a month in 2021–2022 from multi-ethnic patients who were hospitalised and detected to have severe acute respiratory syndrome coronavirus 2 Omicron infection. Details included socio-demographic characteristics, vaccination, and mortality. Patients were subdivided into three groups: Group 1 were admitted with true COVID-19 pneumonitis, Group 2 had incidental COVID-19 on admission screening, and Group 3 were negative on admission but developed COVID-19 over 7 days post-admission. Results: Of 553 patients, only 24.1% (133/553) were in Group 1, 58.2% (322/553) in Group 2, and 17.7% (98/553) in Group 3. Patients in Group 1 and Group 3 were significantly older than those in Group 2 (p<0.001). Thirty percent of patients from Black, Asian, and minority ethnic backgrounds had COVID-19 pneumonitis compared with 19% of those with White ethnicity (p=0.002). Twenty percent of patients were admitted within nonmedical specialties, i.e., surgical specialties, paediatrics, and obstetrics. Of 36 requiring critical care, 21 were in Group 1. Of those patients, 20/21 (95%) were unvaccinated and seven of the 21 who died were all unvaccinated (100%). Common COVID-19 presentations included delirium, falls, seizures, chronic obstructive pulmonary disease, and antenatal problems. Overall, 13.7% (76/553) patients died and 4.7% (26/553) were directly attributable to COVID-19. Conclusions: This large, multi-ethnic study has described clinical presentations and mortality of hospitalised patients with Omicron. It has determined socio-demographic factors associated with these presentations, including ethnicity and vaccination rates. The study provides useful information for future COVID-19 studies examining outcomes and presentations of Omicron and future COVID-19 variants. |
| format | Article |
| id | doaj-art-38e9f3fce96247baa966b1431c8279d5 |
| institution | Kabale University |
| issn | 2397-6764 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal |
| spelling | doaj-art-38e9f3fce96247baa966b1431c8279d52025-01-23T10:31:03ZengEuropean Medical JournalEuropean Medical Journal2397-67642022-11-0110.33590/emj/10174872Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron WaveMehool Patel0Elizabeth Aitken1Lewisham and Greenwich NHS Trust, London, UKLewisham and Greenwich NHS Trust, London, UK Introduction: The objectives of this retrospective study were to describe clinical presentations and mortality outcomes of hospitalised patients with the COVID-19 Omicron variant within two acute district general hospitals, and to evaluate demographic factors associated with these presentations and mortality. Methods: Data was obtained over a month in 2021–2022 from multi-ethnic patients who were hospitalised and detected to have severe acute respiratory syndrome coronavirus 2 Omicron infection. Details included socio-demographic characteristics, vaccination, and mortality. Patients were subdivided into three groups: Group 1 were admitted with true COVID-19 pneumonitis, Group 2 had incidental COVID-19 on admission screening, and Group 3 were negative on admission but developed COVID-19 over 7 days post-admission. Results: Of 553 patients, only 24.1% (133/553) were in Group 1, 58.2% (322/553) in Group 2, and 17.7% (98/553) in Group 3. Patients in Group 1 and Group 3 were significantly older than those in Group 2 (p<0.001). Thirty percent of patients from Black, Asian, and minority ethnic backgrounds had COVID-19 pneumonitis compared with 19% of those with White ethnicity (p=0.002). Twenty percent of patients were admitted within nonmedical specialties, i.e., surgical specialties, paediatrics, and obstetrics. Of 36 requiring critical care, 21 were in Group 1. Of those patients, 20/21 (95%) were unvaccinated and seven of the 21 who died were all unvaccinated (100%). Common COVID-19 presentations included delirium, falls, seizures, chronic obstructive pulmonary disease, and antenatal problems. Overall, 13.7% (76/553) patients died and 4.7% (26/553) were directly attributable to COVID-19. Conclusions: This large, multi-ethnic study has described clinical presentations and mortality of hospitalised patients with Omicron. It has determined socio-demographic factors associated with these presentations, including ethnicity and vaccination rates. The study provides useful information for future COVID-19 studies examining outcomes and presentations of Omicron and future COVID-19 variants.https://www.emjreviews.com/microbiology-infectious-diseases/article/demographic-and-clinical-presentation-of-hospitalised-patients-with-sars-cov-2-during-the-first-omicron-wave |
| spellingShingle | Mehool Patel Elizabeth Aitken Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave European Medical Journal |
| title | Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave |
| title_full | Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave |
| title_fullStr | Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave |
| title_full_unstemmed | Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave |
| title_short | Demographic and Clinical Presentation of Hospitalised Patients with SARS-CoV-2 During the First Omicron Wave |
| title_sort | demographic and clinical presentation of hospitalised patients with sars cov 2 during the first omicron wave |
| url | https://www.emjreviews.com/microbiology-infectious-diseases/article/demographic-and-clinical-presentation-of-hospitalised-patients-with-sars-cov-2-during-the-first-omicron-wave |
| work_keys_str_mv | AT mehoolpatel demographicandclinicalpresentationofhospitalisedpatientswithsarscov2duringthefirstomicronwave AT elizabethaitken demographicandclinicalpresentationofhospitalisedpatientswithsarscov2duringthefirstomicronwave |