Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy
Prostate cancer (PC) can be kept in check by androgen deprivation therapy (ADT, usually with the androgen synthesis inhibitor abiraterone acetate or the androgen receptor antagonist such as enzalutamide) until the tumor evolves to castration-resistant prostate cancer (CRPC). The transition of hormon...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2022-11-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2022a-terrisse-microbial-cell/ |
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| author | Safae Terrisse Laurence Zitvogel Guido Kroemer |
| author_facet | Safae Terrisse Laurence Zitvogel Guido Kroemer |
| author_sort | Safae Terrisse |
| collection | DOAJ |
| description | Prostate cancer (PC) can be kept in check by androgen deprivation therapy (ADT, usually with the androgen synthesis inhibitor abiraterone acetate or the androgen receptor antagonist such as enzalutamide) until the tumor evolves to castration-resistant prostate cancer (CRPC). The transition of hormone-sensitive PC (HSPC) to CPRC has been explained by cancer cell-intrinsic resistance mechanisms. Recent data indicate that this transition is also marked by cancer cell-extrinsic mechanisms such as the failure of ADT-induced PC immunosurveillance, which depends on the presence of immunostimulatory bacteria in the gut. Moreover, intestinal bacteria that degrade drugs used for ADT, as well as bacteria that produce androgens, can interfere with the efficacy of ADT. Thus, specific bacteria in the gut serve as a source of testosterone, which accelerates prostate cancer progression, and men with CRPC exhibit an increased abundance of such bacteria with androgenic functions. In conclusion, the response of PC to ADT is profoundly influenced by the composition of the microbiota with its immunostimulatory, immunosuppressive and directly ADT-subversive elements. |
| format | Article |
| id | doaj-art-38e0ccddcaab4bac9293e84c53674d70 |
| institution | OA Journals |
| issn | 2311-2638 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-38e0ccddcaab4bac9293e84c53674d702025-08-20T02:04:33ZengShared Science Publishers OGMicrobial Cell2311-26382022-11-0191219019410.15698/mic2022.12.787Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapySafae Terrisse0Laurence Zitvogel1Guido Kroemer2Medical Oncology, Hôpital Saint-Louis, Paris, France.INSERM U1015, Equipe Labellisée – Ligue Nationale contre le Cancer, Villejuif, France.Equipe labellisée par la Ligue contre le Cancer, Université de Paris Cité, Sorbonne Université, Institut Universitaire de France, Inserm U1138, Centre de Recherche des Cordeliers, Paris, France.Prostate cancer (PC) can be kept in check by androgen deprivation therapy (ADT, usually with the androgen synthesis inhibitor abiraterone acetate or the androgen receptor antagonist such as enzalutamide) until the tumor evolves to castration-resistant prostate cancer (CRPC). The transition of hormone-sensitive PC (HSPC) to CPRC has been explained by cancer cell-intrinsic resistance mechanisms. Recent data indicate that this transition is also marked by cancer cell-extrinsic mechanisms such as the failure of ADT-induced PC immunosurveillance, which depends on the presence of immunostimulatory bacteria in the gut. Moreover, intestinal bacteria that degrade drugs used for ADT, as well as bacteria that produce androgens, can interfere with the efficacy of ADT. Thus, specific bacteria in the gut serve as a source of testosterone, which accelerates prostate cancer progression, and men with CRPC exhibit an increased abundance of such bacteria with androgenic functions. In conclusion, the response of PC to ADT is profoundly influenced by the composition of the microbiota with its immunostimulatory, immunosuppressive and directly ADT-subversive elements.http://microbialcell.com/researcharticles/2022a-terrisse-microbial-cell/akkermansia muciniphilacastration-resistant prostate cancerhormonotherapymicrobiomeruminococcus gnavus |
| spellingShingle | Safae Terrisse Laurence Zitvogel Guido Kroemer Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy Microbial Cell akkermansia muciniphila castration-resistant prostate cancer hormonotherapy microbiome ruminococcus gnavus |
| title | Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy |
| title_full | Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy |
| title_fullStr | Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy |
| title_full_unstemmed | Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy |
| title_short | Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy |
| title_sort | effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy |
| topic | akkermansia muciniphila castration-resistant prostate cancer hormonotherapy microbiome ruminococcus gnavus |
| url | http://microbialcell.com/researcharticles/2022a-terrisse-microbial-cell/ |
| work_keys_str_mv | AT safaeterrisse effectsoftheintestinalmicrobiotaonprostatecancertreatmentbyandrogendeprivationtherapy AT laurencezitvogel effectsoftheintestinalmicrobiotaonprostatecancertreatmentbyandrogendeprivationtherapy AT guidokroemer effectsoftheintestinalmicrobiotaonprostatecancertreatmentbyandrogendeprivationtherapy |