Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma (ML). Here, we present a case of IVLBCL initially suspected as invasive fungal rhinosinusitis (IFRS). A 64-year-old woman was referred to our hospital due to persistent fever, headache, and rhinorrhea. After admissi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Acta Oto-Laryngologica Case Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/23772484.2024.2306833 |
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| author | Hiroya Yonaga Daisuke Mizokami Saki Takihata Tetsuya Shimada Akihiro Shiotani Koji Araki |
| author_facet | Hiroya Yonaga Daisuke Mizokami Saki Takihata Tetsuya Shimada Akihiro Shiotani Koji Araki |
| author_sort | Hiroya Yonaga |
| collection | DOAJ |
| description | Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma (ML). Here, we present a case of IVLBCL initially suspected as invasive fungal rhinosinusitis (IFRS). A 64-year-old woman was referred to our hospital due to persistent fever, headache, and rhinorrhea. After admission, her overall condition rapidly deteriorated, leading to a diagnosis of septic shock. Blood examination revealed elevated serum lactate dehydrogenase and soluble interleukin 2 receptor levels suggestive of ML. Computed tomography revealed a high-density area with calcifications within the sinus cavity. Although IFRS was the primary suspicion, subsequent endoscopic sinus surgery disconfirmed this hypothesis based on histological findings. Unfortunately, the patient succumbed to multiple organ failure 12 days after admission, with an autopsy confirming IVLBCL. It is crucial to consider IVLBCL as a potential differential diagnosis in cases involving fever of unknown origin and progressive deterioration of the general condition. |
| format | Article |
| id | doaj-art-38dfae865313499bba8fba12efdd0e74 |
| institution | DOAJ |
| issn | 2377-2484 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Acta Oto-Laryngologica Case Reports |
| spelling | doaj-art-38dfae865313499bba8fba12efdd0e742025-08-20T02:49:20ZengTaylor & Francis GroupActa Oto-Laryngologica Case Reports2377-24842024-12-019110.1080/23772484.2024.2306833Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case reportHiroya Yonaga0Daisuke Mizokami1Saki Takihata2Tetsuya Shimada3Akihiro Shiotani4Koji Araki5Department of Otolaryngology, Japan Self Defense Forces Hospital Yokosuka, Kanagawa, JapanDepartment of Otolaryngology-Head & Neck Surgery, Nishisaitama-Chuo National Hospital, Saitama, JapanDepartment of Otolaryngology-Head & Neck Surgery, Nishisaitama-Chuo National Hospital, Saitama, JapanDepartment of Pathology, Nishisaitama-Chuo National Hospital, Saitama, JapanDepartment of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama, JapanDepartment of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama, JapanIntravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma (ML). Here, we present a case of IVLBCL initially suspected as invasive fungal rhinosinusitis (IFRS). A 64-year-old woman was referred to our hospital due to persistent fever, headache, and rhinorrhea. After admission, her overall condition rapidly deteriorated, leading to a diagnosis of septic shock. Blood examination revealed elevated serum lactate dehydrogenase and soluble interleukin 2 receptor levels suggestive of ML. Computed tomography revealed a high-density area with calcifications within the sinus cavity. Although IFRS was the primary suspicion, subsequent endoscopic sinus surgery disconfirmed this hypothesis based on histological findings. Unfortunately, the patient succumbed to multiple organ failure 12 days after admission, with an autopsy confirming IVLBCL. It is crucial to consider IVLBCL as a potential differential diagnosis in cases involving fever of unknown origin and progressive deterioration of the general condition.https://www.tandfonline.com/doi/10.1080/23772484.2024.2306833Intravascular large B-cell lymphomainvasive fungal rhinosinusitisfever of unknown origin |
| spellingShingle | Hiroya Yonaga Daisuke Mizokami Saki Takihata Tetsuya Shimada Akihiro Shiotani Koji Araki Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report Acta Oto-Laryngologica Case Reports Intravascular large B-cell lymphoma invasive fungal rhinosinusitis fever of unknown origin |
| title | Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report |
| title_full | Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report |
| title_fullStr | Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report |
| title_full_unstemmed | Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report |
| title_short | Intravascular large B-cell lymphoma resembling invasive fungal rhinosinusitis: An autopsy case report |
| title_sort | intravascular large b cell lymphoma resembling invasive fungal rhinosinusitis an autopsy case report |
| topic | Intravascular large B-cell lymphoma invasive fungal rhinosinusitis fever of unknown origin |
| url | https://www.tandfonline.com/doi/10.1080/23772484.2024.2306833 |
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