Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism

Purpose. To evaluate glucose and insulin profiles in adolescents with mild stunting and overweight in order to assess the possibility of increased predisposition to diabetes. Subjects and Methods. The study population consisted of 66 pubertal adolescents classified as mildly stunted (height-for-age...

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Main Authors: Carla Danusa da Luz Santos, Ana Paula Grotti Clemente, Vinicius José Baccin Martins, Maria Paula Albuquerque, Ana Lydia Sawaya
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2010/943070
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author Carla Danusa da Luz Santos
Ana Paula Grotti Clemente
Vinicius José Baccin Martins
Maria Paula Albuquerque
Ana Lydia Sawaya
author_facet Carla Danusa da Luz Santos
Ana Paula Grotti Clemente
Vinicius José Baccin Martins
Maria Paula Albuquerque
Ana Lydia Sawaya
author_sort Carla Danusa da Luz Santos
collection DOAJ
description Purpose. To evaluate glucose and insulin profiles in adolescents with mild stunting and overweight in order to assess the possibility of increased predisposition to diabetes. Subjects and Methods. The study population consisted of 66 pubertal adolescents classified as mildly stunted (height-for-age z scores ≥−2 and <−1) or of normal stature, as well as overweight (body mass index ≥85th percentile) or normal weight. Beta-cell function and insulin resistance were evaluated according to the homeostasis model assessment (HOMA). Results. In the group with mild stunting, glucose, insulin, and HOMA-IR levels were significantly higher in overweight adolescents compared with those of normal weight, whereas HOMA-B levels were significantly lower. Adolescents with mild stunting showed significantly higher accumulations of body and abdominal fat than their normal stature counterparts. Conclusions. The presence of mild stunting was associated with higher levels of glucose and insulin, diminished function of beta cells, and increased insulin resistance. These results reinforce the need for intervention in adolescents with mild stunting.
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spelling doaj-art-38dc134b20a640e18cd351a111ec751c2025-08-20T03:55:11ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322010-01-01201010.1155/2010/943070943070Adolescents with Mild Stunting Show Alterations in Glucose and Insulin MetabolismCarla Danusa da Luz Santos0Ana Paula Grotti Clemente1Vinicius José Baccin Martins2Maria Paula Albuquerque3Ana Lydia Sawaya4Department of Physiology, Federal University of São Paulo, São Paulo, 04023-062 SP, BrazilDepartment of Physiology, Federal University of São Paulo, São Paulo, 04023-062 SP, BrazilDepartment of Physiology, Federal University of São Paulo, São Paulo, 04023-062 SP, BrazilNutrition Education and Recovery Center, São Paulo, BrazilDepartment of Physiology, Federal University of São Paulo, São Paulo, 04023-062 SP, BrazilPurpose. To evaluate glucose and insulin profiles in adolescents with mild stunting and overweight in order to assess the possibility of increased predisposition to diabetes. Subjects and Methods. The study population consisted of 66 pubertal adolescents classified as mildly stunted (height-for-age z scores ≥−2 and <−1) or of normal stature, as well as overweight (body mass index ≥85th percentile) or normal weight. Beta-cell function and insulin resistance were evaluated according to the homeostasis model assessment (HOMA). Results. In the group with mild stunting, glucose, insulin, and HOMA-IR levels were significantly higher in overweight adolescents compared with those of normal weight, whereas HOMA-B levels were significantly lower. Adolescents with mild stunting showed significantly higher accumulations of body and abdominal fat than their normal stature counterparts. Conclusions. The presence of mild stunting was associated with higher levels of glucose and insulin, diminished function of beta cells, and increased insulin resistance. These results reinforce the need for intervention in adolescents with mild stunting.http://dx.doi.org/10.1155/2010/943070
spellingShingle Carla Danusa da Luz Santos
Ana Paula Grotti Clemente
Vinicius José Baccin Martins
Maria Paula Albuquerque
Ana Lydia Sawaya
Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism
Journal of Nutrition and Metabolism
title Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism
title_full Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism
title_fullStr Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism
title_full_unstemmed Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism
title_short Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism
title_sort adolescents with mild stunting show alterations in glucose and insulin metabolism
url http://dx.doi.org/10.1155/2010/943070
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