New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities
In present work, new tetra-dentate ligand, titled 3,5-bis ((E)-5-Bromo-2-hydroxy benzylidene amino) benzoic acid (H3L), was prepared via an acid-catalyzed condensation process. New four metallic ligand complexes with Co(II), Ni(II), Cu(II) and Zn(II) ions, were also prepared from the refluxing of eq...
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University of Baghdad, College of Science for Women
2022-02-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5952 |
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| author | Khitam J. Nabhan Amer S. Mahdi Basim H. Al-Zaidi Ahmad H. Ismail Zaizafoone N. Nasif |
| author_facet | Khitam J. Nabhan Amer S. Mahdi Basim H. Al-Zaidi Ahmad H. Ismail Zaizafoone N. Nasif |
| author_sort | Khitam J. Nabhan |
| collection | DOAJ |
| description | In present work, new tetra-dentate ligand, titled 3,5-bis ((E)-5-Bromo-2-hydroxy benzylidene amino) benzoic acid (H3L), was prepared via an acid-catalyzed condensation process. New four metallic ligand complexes with Co(II), Ni(II), Cu(II) and Zn(II) ions, were also prepared from the refluxing of equivalent moles. Ligand's structure and its complexes; were confirmed by numerous characterization methods, including Ultraviolet-Visible, Infrared, Mass Spectrometer, 1H and 13C Nuclear Magnetic Resonance spectra, atomic absorption, magnetic moments, and molar conductivity measurements. The results of the spectroscopic analyzes proved that the prepared ligand acts as tetradentate bi-ionic ligand and it was bonded to the metal ions by two nitrogen atoms of the two azomethine groups and by two oxygen atoms of the two phenolic hydroxyl groups after losing their two protons. Octahedral structure proposed to all prepared complexes. The (anti-bacterial) and (anti-fungal) activities of these compound were screened against (E. coli, S. aureus, Klebsiella spp., S. epidermidis,), and (Candida albicans). The results indicated that these compounds have moderated inhibition behavior. The activity of the prepared compounds against Acetyl Choline Esterase Enzyme (AChE) have also studied and the obtained data indicated the presence of different inhibition behavior. |
| format | Article |
| id | doaj-art-38dbb8200fb54208beea9eb04335af3d |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-38dbb8200fb54208beea9eb04335af3d2025-08-20T02:54:59ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862022-02-0119110.21123/bsj.2022.19.1.0155New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological ActivitiesKhitam J. Nabhan 0Amer S. Mahdi 1Basim H. Al-Zaidi2Ahmad H. Ismail 3Zaizafoone N. Nasif4Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.In present work, new tetra-dentate ligand, titled 3,5-bis ((E)-5-Bromo-2-hydroxy benzylidene amino) benzoic acid (H3L), was prepared via an acid-catalyzed condensation process. New four metallic ligand complexes with Co(II), Ni(II), Cu(II) and Zn(II) ions, were also prepared from the refluxing of equivalent moles. Ligand's structure and its complexes; were confirmed by numerous characterization methods, including Ultraviolet-Visible, Infrared, Mass Spectrometer, 1H and 13C Nuclear Magnetic Resonance spectra, atomic absorption, magnetic moments, and molar conductivity measurements. The results of the spectroscopic analyzes proved that the prepared ligand acts as tetradentate bi-ionic ligand and it was bonded to the metal ions by two nitrogen atoms of the two azomethine groups and by two oxygen atoms of the two phenolic hydroxyl groups after losing their two protons. Octahedral structure proposed to all prepared complexes. The (anti-bacterial) and (anti-fungal) activities of these compound were screened against (E. coli, S. aureus, Klebsiella spp., S. epidermidis,), and (Candida albicans). The results indicated that these compounds have moderated inhibition behavior. The activity of the prepared compounds against Acetyl Choline Esterase Enzyme (AChE) have also studied and the obtained data indicated the presence of different inhibition behavior.https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5952Tetradentate (N2O2) Schiff base complexes, acetylcholinesterase (AChE) activity, Anti-bacterial and antifungal. |
| spellingShingle | Khitam J. Nabhan Amer S. Mahdi Basim H. Al-Zaidi Ahmad H. Ismail Zaizafoone N. Nasif New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities مجلة بغداد للعلوم Tetradentate (N2O2) Schiff base complexes, acetylcholinesterase (AChE) activity, Anti-bacterial and antifungal. |
| title | New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities |
| title_full | New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities |
| title_fullStr | New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities |
| title_full_unstemmed | New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities |
| title_short | New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities |
| title_sort | new tetra dentate schiff base ligand n2o2 and its complexes with some of metal ions preparation identification and studying their enzymatic and biological activities |
| topic | Tetradentate (N2O2) Schiff base complexes, acetylcholinesterase (AChE) activity, Anti-bacterial and antifungal. |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5952 |
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