Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up
Aim: to present a clinical observation of a patient with Whipple's disease, demonstrating the difficulties in diagnosing the disease.Key points. A clinical observation of Whipple's disease in a 61-year-old man is described. The onset of the disease was manifested as polyarthritis three yea...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2024-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/966 |
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| author | Zh. G. Simonova О. V. Pestereva D. A. Dyakonov М. А. Karepanov М. S. Ralnikova |
| author_facet | Zh. G. Simonova О. V. Pestereva D. A. Dyakonov М. А. Karepanov М. S. Ralnikova |
| author_sort | Zh. G. Simonova |
| collection | DOAJ |
| description | Aim: to present a clinical observation of a patient with Whipple's disease, demonstrating the difficulties in diagnosing the disease.Key points. A clinical observation of Whipple's disease in a 61-year-old man is described. The onset of the disease was manifested as polyarthritis three years before diagnosis. The further course of the disease occurred during the pandemic of a new coronavirus infection COVID-19, which made the diagnostic search difficult. Clinical manifestations of fever, arthralgias, diarrhea, lymphadenopathy, anaemia and weight loss raised suspicion of Whipple's disease. Key to the diagnosis were endoscopic studies with multiple small bowel biopsies, which allowed histological identification of PAS-positive macrophages in the small bowel mucosa. Therapy with ceftriaxone for 14 days, therapy with trimethoprim-sulfamethoxazole (160 mg/800 mg twice a day) for 14 months resulted in positive clinical dynamics, improvement of laboratory parameters, disappearance of PAS-positive macrophages in the small intestinal mucosa, indicating remission of the disease. |
| format | Article |
| id | doaj-art-38db8048248f4c0c8c4f25bb640e8008 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-38db8048248f4c0c8c4f25bb640e80082025-02-10T16:14:39ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-05-013429110010.22416/1382-4376-2024-34-2-91-100760Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-UpZh. G. Simonova0О. V. Pestereva1D. A. Dyakonov2М. А. Karepanov3М. S. Ralnikova4Kirov State Medical UniversityKirov State Medical UniversityKirov Research Institute of Haematology and Blood Transfusion of the Federal Medical and Biological AgencyKirov Regional Clinical HospitalKirov Regional Clinical HospitalAim: to present a clinical observation of a patient with Whipple's disease, demonstrating the difficulties in diagnosing the disease.Key points. A clinical observation of Whipple's disease in a 61-year-old man is described. The onset of the disease was manifested as polyarthritis three years before diagnosis. The further course of the disease occurred during the pandemic of a new coronavirus infection COVID-19, which made the diagnostic search difficult. Clinical manifestations of fever, arthralgias, diarrhea, lymphadenopathy, anaemia and weight loss raised suspicion of Whipple's disease. Key to the diagnosis were endoscopic studies with multiple small bowel biopsies, which allowed histological identification of PAS-positive macrophages in the small bowel mucosa. Therapy with ceftriaxone for 14 days, therapy with trimethoprim-sulfamethoxazole (160 mg/800 mg twice a day) for 14 months resulted in positive clinical dynamics, improvement of laboratory parameters, disappearance of PAS-positive macrophages in the small intestinal mucosa, indicating remission of the disease.https://www.gastro-j.ru/jour/article/view/966whipple's diseasepas-positive macrophageslymphadenopathyjoint syndromediarrheaanaemia |
| spellingShingle | Zh. G. Simonova О. V. Pestereva D. A. Dyakonov М. А. Karepanov М. S. Ralnikova Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up Российский журнал гастроэнтерологии, гепатологии, колопроктологии whipple's disease pas-positive macrophages lymphadenopathy joint syndrome diarrhea anaemia |
| title | Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up |
| title_full | Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up |
| title_fullStr | Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up |
| title_full_unstemmed | Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up |
| title_short | Whipple's Disease in a 61-Year-Old Patient. Clinical Follow-Up |
| title_sort | whipple s disease in a 61 year old patient clinical follow up |
| topic | whipple's disease pas-positive macrophages lymphadenopathy joint syndrome diarrhea anaemia |
| url | https://www.gastro-j.ru/jour/article/view/966 |
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