Iron Loading and Overloading due to Ineffective Erythropoiesis
Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contain...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2010/358283 |
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| author | Toshihiko Tanno Jeffery L. Miller |
| author_facet | Toshihiko Tanno Jeffery L. Miller |
| author_sort | Toshihiko Tanno |
| collection | DOAJ |
| description | Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contained within each erythrocyte. Thus, iron usage for the hemoglobin production is a primary regulator of plasma iron supply and demand. In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand. Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion. The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood. Based upon data that is currently available, it is proposed in this review that loading and overloading of iron can be regulated by distinct or combined mechanisms associated with erythropoiesis. The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis. |
| format | Article |
| id | doaj-art-38d9ca0310424a5bafb6b9acfd345cf1 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-38d9ca0310424a5bafb6b9acfd345cf12025-02-03T01:06:48ZengWileyAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/358283358283Iron Loading and Overloading due to Ineffective ErythropoiesisToshihiko Tanno0Jeffery L. Miller1Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USAMolecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USAErythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contained within each erythrocyte. Thus, iron usage for the hemoglobin production is a primary regulator of plasma iron supply and demand. In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand. Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion. The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood. Based upon data that is currently available, it is proposed in this review that loading and overloading of iron can be regulated by distinct or combined mechanisms associated with erythropoiesis. The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis.http://dx.doi.org/10.1155/2010/358283 |
| spellingShingle | Toshihiko Tanno Jeffery L. Miller Iron Loading and Overloading due to Ineffective Erythropoiesis Advances in Hematology |
| title | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| title_full | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| title_fullStr | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| title_full_unstemmed | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| title_short | Iron Loading and Overloading due to Ineffective Erythropoiesis |
| title_sort | iron loading and overloading due to ineffective erythropoiesis |
| url | http://dx.doi.org/10.1155/2010/358283 |
| work_keys_str_mv | AT toshihikotanno ironloadingandoverloadingduetoineffectiveerythropoiesis AT jefferylmiller ironloadingandoverloadingduetoineffectiveerythropoiesis |