Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer
Cervical cancer is a common malignant tumor in women, and human papillomavirus (HPV) infection is a major cause of cervical cancer. Tumor-infiltrating lymphocytes (TILs) are a heterogeneous group of lymphocytes primarily composed of T lymphocytes found within the tumor parenchyma and stroma. These c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524842/full |
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| author | Wei Zhang Wei Zhang Yong-Min Liu Dong Li Shan Liu Xiao-Jun Cai Ji-Ying Tang Zhi-Gang Zuo Xin-Hui Li Yi Zhao |
| author_facet | Wei Zhang Wei Zhang Yong-Min Liu Dong Li Shan Liu Xiao-Jun Cai Ji-Ying Tang Zhi-Gang Zuo Xin-Hui Li Yi Zhao |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Cervical cancer is a common malignant tumor in women, and human papillomavirus (HPV) infection is a major cause of cervical cancer. Tumor-infiltrating lymphocytes (TILs) are a heterogeneous group of lymphocytes primarily composed of T lymphocytes found within the tumor parenchyma and stroma. These cells can be isolated from tumor tissue, activated, expanded in vitro, and reinfused into the patient to exert an anti-tumor immune effect. As a form of personalized immunotherapy, TILs therapy has shown satisfactory efficacy and safety in advanced recurrent and metastatic cervical cancer, offering new hope to patients with advanced cervical cancer. However, TILs therapy for advanced cervical cancer still faces several limitations and challenges. This article reviews the process and latest developments in TILs therapy for advanced cervical cancer and discusses the challenges in the usage and prospects for this treatment. |
| format | Article |
| id | doaj-art-38d893a7f3394050b56ffc86776c9cbc |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-38d893a7f3394050b56ffc86776c9cbc2025-08-20T03:53:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15248421524842Research progress on tumor-infiltrating lymphocyte therapy for cervical cancerWei Zhang0Wei Zhang1Yong-Min Liu2Dong Li3Shan Liu4Xiao-Jun Cai5Ji-Ying Tang6Zhi-Gang Zuo7Xin-Hui Li8Yi Zhao9Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaInstitute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaCervical cancer is a common malignant tumor in women, and human papillomavirus (HPV) infection is a major cause of cervical cancer. Tumor-infiltrating lymphocytes (TILs) are a heterogeneous group of lymphocytes primarily composed of T lymphocytes found within the tumor parenchyma and stroma. These cells can be isolated from tumor tissue, activated, expanded in vitro, and reinfused into the patient to exert an anti-tumor immune effect. As a form of personalized immunotherapy, TILs therapy has shown satisfactory efficacy and safety in advanced recurrent and metastatic cervical cancer, offering new hope to patients with advanced cervical cancer. However, TILs therapy for advanced cervical cancer still faces several limitations and challenges. This article reviews the process and latest developments in TILs therapy for advanced cervical cancer and discusses the challenges in the usage and prospects for this treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524842/fullcervical cancertumor-infiltrating lymphocytes (TILs)immunotherapyTILs therapyhuman papillomavirus |
| spellingShingle | Wei Zhang Wei Zhang Yong-Min Liu Dong Li Shan Liu Xiao-Jun Cai Ji-Ying Tang Zhi-Gang Zuo Xin-Hui Li Yi Zhao Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer Frontiers in Immunology cervical cancer tumor-infiltrating lymphocytes (TILs) immunotherapy TILs therapy human papillomavirus |
| title | Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer |
| title_full | Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer |
| title_fullStr | Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer |
| title_full_unstemmed | Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer |
| title_short | Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer |
| title_sort | research progress on tumor infiltrating lymphocyte therapy for cervical cancer |
| topic | cervical cancer tumor-infiltrating lymphocytes (TILs) immunotherapy TILs therapy human papillomavirus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524842/full |
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