Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study
Aim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high >0.84%, moderate 0.13%–0.84%, and low <0.13%....
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2010/736391 |
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| author | Joonas Sirola Anna-Kaisa Koistinen Kari Salovaara Toni Rikkonen Marjo Tuppurainen Jukka S. Jurvelin Risto Honkanen Esko Alhava Heikki Kröger |
| author_facet | Joonas Sirola Anna-Kaisa Koistinen Kari Salovaara Toni Rikkonen Marjo Tuppurainen Jukka S. Jurvelin Risto Honkanen Esko Alhava Heikki Kröger |
| author_sort | Joonas Sirola |
| collection | DOAJ |
| description | Aim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high >0.84%, moderate 0.13%–0.84%, and low <0.13%. Low trauma energy fractures during following 10 years were recorded. There were no differences in FR between BL tertiles in Cox regression model. Factors predicting lower FR in Cox model were in high tertile: high T-score (HR 0.71; 95% CI 0.54–0.93, P=.012), no sister's fracture (HR 0.35; 0.19–0.64, P=.001), no mother's fracture (HR 0.52; 0.31–0.88, P=.015), in moderate tertile: high T-score (HR 0.69;0.53–0.91, P=.008) and good grip strength (HR 0.98; 0.97–0.99, P=.022). In low tertile there were no predictors for FR. BL predicted FR in women with mother's fracture in univariate and multivariate model (OR 2.6; 1.15–5.7, P=.021) but with sister's fracture this was observed only in multivariate model (OR 2.66; 1.09–6.7, P=.039). Accordingly, the risk factors for postmenopausal fractures, especially mother's fracture, may interact with BL. |
| format | Article |
| id | doaj-art-38d812fbc8774d77a69d32ee3c16b30e |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-38d812fbc8774d77a69d32ee3c16b30e2025-02-03T01:32:38ZengWileyJournal of Osteoporosis2042-00642010-01-01201010.4061/2010/736391736391Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based StudyJoonas Sirola0Anna-Kaisa Koistinen1Kari Salovaara2Toni Rikkonen3Marjo Tuppurainen4Jukka S. Jurvelin5Risto Honkanen6Esko Alhava7Heikki Kröger8Bone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandBone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandBone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandBone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandBone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandDepartment of Clinical Physiology & Nuclear Medicine, Kuopio University Hospital, 70211 Kuopio, FinlandBone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandDepartment of Surgery, Kuopio University Hospital, 70211 Kuopio, FinlandBone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, FinlandAim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high >0.84%, moderate 0.13%–0.84%, and low <0.13%. Low trauma energy fractures during following 10 years were recorded. There were no differences in FR between BL tertiles in Cox regression model. Factors predicting lower FR in Cox model were in high tertile: high T-score (HR 0.71; 95% CI 0.54–0.93, P=.012), no sister's fracture (HR 0.35; 0.19–0.64, P=.001), no mother's fracture (HR 0.52; 0.31–0.88, P=.015), in moderate tertile: high T-score (HR 0.69;0.53–0.91, P=.008) and good grip strength (HR 0.98; 0.97–0.99, P=.022). In low tertile there were no predictors for FR. BL predicted FR in women with mother's fracture in univariate and multivariate model (OR 2.6; 1.15–5.7, P=.021) but with sister's fracture this was observed only in multivariate model (OR 2.66; 1.09–6.7, P=.039). Accordingly, the risk factors for postmenopausal fractures, especially mother's fracture, may interact with BL.http://dx.doi.org/10.4061/2010/736391 |
| spellingShingle | Joonas Sirola Anna-Kaisa Koistinen Kari Salovaara Toni Rikkonen Marjo Tuppurainen Jukka S. Jurvelin Risto Honkanen Esko Alhava Heikki Kröger Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study Journal of Osteoporosis |
| title | Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study |
| title_full | Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study |
| title_fullStr | Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study |
| title_full_unstemmed | Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study |
| title_short | Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study |
| title_sort | bone loss rate may interact with other risk factors for fractures among elderly women a 15 year population based study |
| url | http://dx.doi.org/10.4061/2010/736391 |
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