Mechanism and application of lactylation in cancers

Mechanism and application of lactylation in cancers

Abstract Lactate is a crucial product of cancer metabolism, creating an acidic environment that supports cancer growth and acts as a substrate for lactylation. Lactylation, a newly discovered epigenetic modification, plays a vital role in cancer cell signaling, metabolic reprogramming, immune respon...

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Bibliographic Details
Main Authors: Jiewen Wang, Mingjing Peng, Linda Oyang, Mengzhou Shen, Shizhen Li, Xianjie Jiang, Zongyao Ren, Qiu Peng, Xuemeng Xu, Shiming Tan, Longzheng Xia, Wenjuan Yang, Haofan Li, Nayiyuan Wu, Yanyan Tang, Jinguan Lin, Qianjin Liao, Yaqian Han, Yujuan Zhou
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell & Bioscience
Subjects:
Lactylation
Cancer resistance
Immunotherapy
Cancer
Online Access:https://doi.org/10.1186/s13578-025-01415-9
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