The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients
Abstract Whether the fat-soluble vitamins A, D, E, and K are associated with development of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation, is unclear. We assessed if the levels of these vitamins were associated with development of GvHD during the first year after transp...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-84805-2 |
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| author | Kristin J. Skaarud Anne Marte Gudmundstuen Maiju Pesonen Marianne J. Hjermstad Per Ole Iversen Geir E. Tjønnfjord |
| author_facet | Kristin J. Skaarud Anne Marte Gudmundstuen Maiju Pesonen Marianne J. Hjermstad Per Ole Iversen Geir E. Tjønnfjord |
| author_sort | Kristin J. Skaarud |
| collection | DOAJ |
| description | Abstract Whether the fat-soluble vitamins A, D, E, and K are associated with development of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation, is unclear. We assessed if the levels of these vitamins were associated with development of GvHD during the first year after transplantation using data from a two-armed randomized nutritional intervention trial. Changes in plasma levels during 1-year follow-up were analyzed using a linear mixed model for repeated measurements. Vitamin A, D, E, and K levels changed significantly the first year in both study arms (p < 0.001). Higher levels of vitamin E over time were associated with less acute GvHD grades 3–4 (OR = 0.997, 95% CI: (0.994, 0.999), p = 0.017). No associations were found with vitamin A, D, E and K levels and chronic GvHD. Multivariable analysis adjusted for treatment group, age, pre-transplant vitamin level and risk factors for GvHD did not change the results. Six weeks post-transplantation, higher levels of vitamin E were associated with less acute GvHD grades 3–4, (p = 0.012). In conclusion, we found an association between higher levels of vitamin E over time and less severe acute GvHD. Whether this reflects a causal relationship warrants further study. ClinicalTrials.gov (NCT01181076). |
| format | Article |
| id | doaj-art-38d2eaa586834ce3a0bb5a76bd055c3b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-38d2eaa586834ce3a0bb5a76bd055c3b2025-01-12T12:15:14ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84805-2The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patientsKristin J. Skaarud0Anne Marte Gudmundstuen1Maiju Pesonen2Marianne J. Hjermstad3Per Ole Iversen4Geir E. Tjønnfjord5Department of Haematology, Oslo University HospitalDepartment of Haematology, Oslo University HospitalDepartment of Biostatistics, Institute of Medical Sciences, University of OsloEuropean Care Palliative Research Centre (PRC), Department of Oncology, Oslo University Hospital/Institute of Clinical Medicine, University of OsloDepartment of Haematology, Oslo University HospitalDepartment of Haematology, Oslo University HospitalAbstract Whether the fat-soluble vitamins A, D, E, and K are associated with development of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation, is unclear. We assessed if the levels of these vitamins were associated with development of GvHD during the first year after transplantation using data from a two-armed randomized nutritional intervention trial. Changes in plasma levels during 1-year follow-up were analyzed using a linear mixed model for repeated measurements. Vitamin A, D, E, and K levels changed significantly the first year in both study arms (p < 0.001). Higher levels of vitamin E over time were associated with less acute GvHD grades 3–4 (OR = 0.997, 95% CI: (0.994, 0.999), p = 0.017). No associations were found with vitamin A, D, E and K levels and chronic GvHD. Multivariable analysis adjusted for treatment group, age, pre-transplant vitamin level and risk factors for GvHD did not change the results. Six weeks post-transplantation, higher levels of vitamin E were associated with less acute GvHD grades 3–4, (p = 0.012). In conclusion, we found an association between higher levels of vitamin E over time and less severe acute GvHD. Whether this reflects a causal relationship warrants further study. ClinicalTrials.gov (NCT01181076).https://doi.org/10.1038/s41598-024-84805-2 |
| spellingShingle | Kristin J. Skaarud Anne Marte Gudmundstuen Maiju Pesonen Marianne J. Hjermstad Per Ole Iversen Geir E. Tjønnfjord The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients Scientific Reports |
| title | The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients |
| title_full | The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients |
| title_fullStr | The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients |
| title_full_unstemmed | The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients |
| title_short | The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients |
| title_sort | role of fat soluble vitamins for graft versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients |
| url | https://doi.org/10.1038/s41598-024-84805-2 |
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