Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis

Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis

Abstract Osteoarthritis (OA) is an age‐related degenerative joint disease, prominently influenced by the pro‐inflammatory cytokine interleukin‐6 (IL‐6). Although elevated IL‐6 levels in joint fluid are well‐documented, the uneven cartilage degeneration observed in knee OA patients suggests additiona...

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Bibliographic Details
Main Authors: Xiang Zhao, Jieming Lin, Feng Liu, Yu Zhang, Bo Shi, Chunhui Ma, Ziqi Wang, Song Xue, Qingrong Xu, Hongda Shao, Jingxing Yang, Yanzheng Gao
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cartilage degeneration
interleukin‐6 receptor
JAK2 signaling
osteoarthritis
senescent cells
Online Access:https://doi.org/10.1002/advs.202410795
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