The impact of thyroid hormones on patients with hepatocellular carcinoma.
<h4>Background & aims</h4>Hypothyroidism has recently been proposed as predisposing factor for HCC development. However, the role of thyroid hormones (TH) in established HCC is largely unclear. We investigated the impact of TH on clinical characteristics and prognosis of HCC patients...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181878&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850230135787094016 |
|---|---|
| author | Matthias Pinter Lukas Haupt Florian Hucke Simona Bota Theresa Bucsics Michael Trauner Markus Peck-Radosavljevic Wolfgang Sieghart |
| author_facet | Matthias Pinter Lukas Haupt Florian Hucke Simona Bota Theresa Bucsics Michael Trauner Markus Peck-Radosavljevic Wolfgang Sieghart |
| author_sort | Matthias Pinter |
| collection | DOAJ |
| description | <h4>Background & aims</h4>Hypothyroidism has recently been proposed as predisposing factor for HCC development. However, the role of thyroid hormones (TH) in established HCC is largely unclear. We investigated the impact of TH on clinical characteristics and prognosis of HCC patients.<h4>Methods</h4>Of 838 patients diagnosed with nonsurgical HCC at the Division of Gastroenterology and Hepatology/Medical University of Vienna between 1992 and 2012, 667 patients fulfilled the inclusion criteria. The associations of thyroid function tests with patient, liver, and tumor characteristics as well as their impact on overall survival (OS) were investigated.<h4>Results</h4>Thyroid hormone substitution was more often observed in patients with low thyroid-stimulating hormone (TSH) concentration and in patients with elevated free tetraiodthyronine (fT4). Patients with high TSH (>3.77uU/ml) concentrations had larger tumors, while the opposite was true for patients with low TSH (<0.44uU/ml) concentrations. Subjects with elevated fT4 (>1.66ng/dl) were more likely to have elevated CRP. While TSH was only associated with OS in univariate analysis (≤1.7 vs. >1.7uU/ml, median OS (95%CI), 12.3 (8.9-15.7 months) vs. 7.3 months (5.4-9.2 months); p = 0.003), fT4 (≤1.66 vs. >1.66ng/dl, median OS (95%CI), 10.6 (7.5-13.6 months) vs. 3.3 months (2.2-4.3 months); p = 0.007) remained an independent prognostic factor for OS (HR (95%CI) for fT4>1.66ng/dl, 2.1 (1.3-3.3); p = 0.002) in multivariate analysis.<h4>Conclusions</h4>TSH and fT4 were associated with prognostic factors of HCC (i.e., tumor size, CRP level). Elevated fT4 concentrations were independently associated with poor prognosis in HCC. Further studies are needed to characterize the role of TH in HCC in detail. |
| format | Article |
| id | doaj-art-38cf4302b50c4708a769c6a6ded4d5fc |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-38cf4302b50c4708a769c6a6ded4d5fc2025-08-20T02:03:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018187810.1371/journal.pone.0181878The impact of thyroid hormones on patients with hepatocellular carcinoma.Matthias PinterLukas HauptFlorian HuckeSimona BotaTheresa BucsicsMichael TraunerMarkus Peck-RadosavljevicWolfgang Sieghart<h4>Background & aims</h4>Hypothyroidism has recently been proposed as predisposing factor for HCC development. However, the role of thyroid hormones (TH) in established HCC is largely unclear. We investigated the impact of TH on clinical characteristics and prognosis of HCC patients.<h4>Methods</h4>Of 838 patients diagnosed with nonsurgical HCC at the Division of Gastroenterology and Hepatology/Medical University of Vienna between 1992 and 2012, 667 patients fulfilled the inclusion criteria. The associations of thyroid function tests with patient, liver, and tumor characteristics as well as their impact on overall survival (OS) were investigated.<h4>Results</h4>Thyroid hormone substitution was more often observed in patients with low thyroid-stimulating hormone (TSH) concentration and in patients with elevated free tetraiodthyronine (fT4). Patients with high TSH (>3.77uU/ml) concentrations had larger tumors, while the opposite was true for patients with low TSH (<0.44uU/ml) concentrations. Subjects with elevated fT4 (>1.66ng/dl) were more likely to have elevated CRP. While TSH was only associated with OS in univariate analysis (≤1.7 vs. >1.7uU/ml, median OS (95%CI), 12.3 (8.9-15.7 months) vs. 7.3 months (5.4-9.2 months); p = 0.003), fT4 (≤1.66 vs. >1.66ng/dl, median OS (95%CI), 10.6 (7.5-13.6 months) vs. 3.3 months (2.2-4.3 months); p = 0.007) remained an independent prognostic factor for OS (HR (95%CI) for fT4>1.66ng/dl, 2.1 (1.3-3.3); p = 0.002) in multivariate analysis.<h4>Conclusions</h4>TSH and fT4 were associated with prognostic factors of HCC (i.e., tumor size, CRP level). Elevated fT4 concentrations were independently associated with poor prognosis in HCC. Further studies are needed to characterize the role of TH in HCC in detail.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181878&type=printable |
| spellingShingle | Matthias Pinter Lukas Haupt Florian Hucke Simona Bota Theresa Bucsics Michael Trauner Markus Peck-Radosavljevic Wolfgang Sieghart The impact of thyroid hormones on patients with hepatocellular carcinoma. PLoS ONE |
| title | The impact of thyroid hormones on patients with hepatocellular carcinoma. |
| title_full | The impact of thyroid hormones on patients with hepatocellular carcinoma. |
| title_fullStr | The impact of thyroid hormones on patients with hepatocellular carcinoma. |
| title_full_unstemmed | The impact of thyroid hormones on patients with hepatocellular carcinoma. |
| title_short | The impact of thyroid hormones on patients with hepatocellular carcinoma. |
| title_sort | impact of thyroid hormones on patients with hepatocellular carcinoma |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181878&type=printable |
| work_keys_str_mv | AT matthiaspinter theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT lukashaupt theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT florianhucke theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT simonabota theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT theresabucsics theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT michaeltrauner theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT markuspeckradosavljevic theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT wolfgangsieghart theimpactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT matthiaspinter impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT lukashaupt impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT florianhucke impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT simonabota impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT theresabucsics impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT michaeltrauner impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT markuspeckradosavljevic impactofthyroidhormonesonpatientswithhepatocellularcarcinoma AT wolfgangsieghart impactofthyroidhormonesonpatientswithhepatocellularcarcinoma |