A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear
Sickle cell anaemia causes significant mortality and morbidity, with a decrease of 25–30 years in the average life expectancy. Over time, sickle cell disease produces various musculoskeletal abnormalities as a result of chronic anaemia. Ischaemia and infarction are the common complications that may...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jcsr.jcsr_73_21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849420788458848256 |
|---|---|
| author | Naval Chandra Sunkesula Abdul Rajak Azigiri Sri Nanditha Vydugula Sharanya Swaroopa Reddy Deme Bobbili Krishna Chaithanya |
| author_facet | Naval Chandra Sunkesula Abdul Rajak Azigiri Sri Nanditha Vydugula Sharanya Swaroopa Reddy Deme Bobbili Krishna Chaithanya |
| author_sort | Naval Chandra |
| collection | DOAJ |
| description | Sickle cell anaemia causes significant mortality and morbidity, with a decrease of 25–30 years in the average life expectancy. Over time, sickle cell disease produces various musculoskeletal abnormalities as a result of chronic anaemia. Ischaemia and infarction are the common complications that may have long-term effects on the growth of bone; both infection and infarction may occur in muscle and soft tissue alone, without involving bone. Vasoocclusion may occur in muscle and lead to inflammation, oedema and myonecrosis. Fluid collections, haematomas and fat necrosis may occur in the soft tissue. We report a case of an adult male presenting with musculoskeletal manifestations and normal peripheral smear. The patient was diagnosed to have sickle cell disease and was managed accordingly. |
| format | Article |
| id | doaj-art-38cec854eaca4729a8bef4e8df850367 |
| institution | Kabale University |
| issn | 2277-5706 2277-8357 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj-art-38cec854eaca4729a8bef4e8df8503672025-08-20T03:31:38ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572025-01-01141606310.4103/jcsr.jcsr_73_21A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smearNaval ChandraSunkesula Abdul RajakAzigiri Sri NandithaVydugula SharanyaSwaroopa Reddy DemeBobbili Krishna ChaithanyaSickle cell anaemia causes significant mortality and morbidity, with a decrease of 25–30 years in the average life expectancy. Over time, sickle cell disease produces various musculoskeletal abnormalities as a result of chronic anaemia. Ischaemia and infarction are the common complications that may have long-term effects on the growth of bone; both infection and infarction may occur in muscle and soft tissue alone, without involving bone. Vasoocclusion may occur in muscle and lead to inflammation, oedema and myonecrosis. Fluid collections, haematomas and fat necrosis may occur in the soft tissue. We report a case of an adult male presenting with musculoskeletal manifestations and normal peripheral smear. The patient was diagnosed to have sickle cell disease and was managed accordingly.https://journals.lww.com/10.4103/jcsr.jcsr_73_21anaemiahaemoglobininfarctionischaemiamusculoskeletalsickle |
| spellingShingle | Naval Chandra Sunkesula Abdul Rajak Azigiri Sri Nanditha Vydugula Sharanya Swaroopa Reddy Deme Bobbili Krishna Chaithanya A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear Journal of Clinical and Scientific Research anaemia haemoglobin infarction ischaemia musculoskeletal sickle |
| title | A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear |
| title_full | A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear |
| title_fullStr | A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear |
| title_full_unstemmed | A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear |
| title_short | A rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear |
| title_sort | rare case of sickle cell disease with musculoskeletal manifestations and normal peripheral smear |
| topic | anaemia haemoglobin infarction ischaemia musculoskeletal sickle |
| url | https://journals.lww.com/10.4103/jcsr.jcsr_73_21 |
| work_keys_str_mv | AT navalchandra ararecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT sunkesulaabdulrajak ararecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT azigirisrinanditha ararecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT vydugulasharanya ararecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT swaroopareddydeme ararecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT bobbilikrishnachaithanya ararecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT navalchandra rarecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT sunkesulaabdulrajak rarecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT azigirisrinanditha rarecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT vydugulasharanya rarecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT swaroopareddydeme rarecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear AT bobbilikrishnachaithanya rarecaseofsicklecelldiseasewithmusculoskeletalmanifestationsandnormalperipheralsmear |