Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report
[Objective] To investigate the clinical symptoms, laboratory tests, and treatment strategies of a case of fetal/neonatal alloimmune thrombocytopenia (FNAIT) complicated with piperacillin drug antibody. [Methods] The platelet antibodies in the mother were screened and identified by ELISA. The HLA ant...
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| Format: | Article |
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-07-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.016&lang=en |
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| author | MENG Zifan ZHANG Shaoqiang JU Qiang LI Ying YAN Songxia WANG Haiyan |
| author_facet | MENG Zifan ZHANG Shaoqiang JU Qiang LI Ying YAN Songxia WANG Haiyan |
| author_sort | MENG Zifan |
| collection | DOAJ |
| description | [Objective] To investigate the clinical symptoms, laboratory tests, and treatment strategies of a case of fetal/neonatal alloimmune thrombocytopenia (FNAIT) complicated with piperacillin drug antibody. [Methods] The platelet antibodies in the mother were screened and identified by ELISA. The HLA antigens of the newborn were genotyped through PCR-SSO, while the specificity of HLA antibodies in the mother was determined using a Single Antigen kit. The drug antibody was detected by a piperacillin kit. [Results] Maternal antibodies against paternally-derived platelet antigens were detected. The HLA genotypes of the newborn were identified as HLA A* 33∶03 and HLA B* 58∶01. The mother exhibited strong positive antibodies against the specific platelet antigens of the newborn, namely anti-HLA-A33 and anti-HLA-B58 antibodies. The piperacillin antibody was detected in the newborn. Following treatment of continuous intravenous immunoglobulin (IVIG), platelet transfusions, red blood cell transfusions and discontinuation of piperacillin treatment, the platelet count and hemoglobin levels increased in the newborn. [Conclusion] The newborn in this case was diagnosed with FNAIT complicated by the presence of anti-HLA-A33 and anti-HLA-B58 antibodies, as well as drug-induced hemolytic anemia caused by piperacillin drug antibody. The condition is more complicated under the influence of dual immune antibodies. Laboratory detection techniques such as platelet antibody and drug antibody tests can assist in early clinical diagnosis. At the same time, more active drug and blood transfusion treatments should be given in clinical practice to improve the prognosis. |
| format | Article |
| id | doaj-art-38ca4ecbecc545b7832c0cfef59369ca |
| institution | DOAJ |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-38ca4ecbecc545b7832c0cfef59369ca2025-08-20T03:23:16ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-07-0138796997410.13303/j.cjbt.issn.1004-549x.2025.07.0161004-549X(2025)7-0969-06Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case reportMENG Zifan0ZHANG Shaoqiang1JU Qiang2LI Ying3YAN Songxia4WANG Haiyan5Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266000, China[Objective] To investigate the clinical symptoms, laboratory tests, and treatment strategies of a case of fetal/neonatal alloimmune thrombocytopenia (FNAIT) complicated with piperacillin drug antibody. [Methods] The platelet antibodies in the mother were screened and identified by ELISA. The HLA antigens of the newborn were genotyped through PCR-SSO, while the specificity of HLA antibodies in the mother was determined using a Single Antigen kit. The drug antibody was detected by a piperacillin kit. [Results] Maternal antibodies against paternally-derived platelet antigens were detected. The HLA genotypes of the newborn were identified as HLA A* 33∶03 and HLA B* 58∶01. The mother exhibited strong positive antibodies against the specific platelet antigens of the newborn, namely anti-HLA-A33 and anti-HLA-B58 antibodies. The piperacillin antibody was detected in the newborn. Following treatment of continuous intravenous immunoglobulin (IVIG), platelet transfusions, red blood cell transfusions and discontinuation of piperacillin treatment, the platelet count and hemoglobin levels increased in the newborn. [Conclusion] The newborn in this case was diagnosed with FNAIT complicated by the presence of anti-HLA-A33 and anti-HLA-B58 antibodies, as well as drug-induced hemolytic anemia caused by piperacillin drug antibody. The condition is more complicated under the influence of dual immune antibodies. Laboratory detection techniques such as platelet antibody and drug antibody tests can assist in early clinical diagnosis. At the same time, more active drug and blood transfusion treatments should be given in clinical practice to improve the prognosis.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.016&lang=enfetal/ neonatal alloimmune thrombocytopenia (fnait)hla antibodypiperacillin drug antibodydrug-induced immune hemolytic anemia |
| spellingShingle | MENG Zifan ZHANG Shaoqiang JU Qiang LI Ying YAN Songxia WANG Haiyan Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report Zhongguo shuxue zazhi fetal/ neonatal alloimmune thrombocytopenia (fnait) hla antibody piperacillin drug antibody drug-induced immune hemolytic anemia |
| title | Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report |
| title_full | Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report |
| title_fullStr | Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report |
| title_full_unstemmed | Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report |
| title_short | Neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody: a case report |
| title_sort | neonatal alloimmune thrombocytopenia complicated with piperacillin drug antibody a case report |
| topic | fetal/ neonatal alloimmune thrombocytopenia (fnait) hla antibody piperacillin drug antibody drug-induced immune hemolytic anemia |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.016&lang=en |
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