Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis

Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis

Abstract Background Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. This modification forms large chromatin domains, known as Large Organized Chromatin Lysine Domains (LOCKs), which span several hundred kilobases. R...

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Bibliographic Details
Main Authors: Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin, Yueyuan Zheng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Epigenetics & Chromatin
Subjects:
H3K27me3 modification
DNA methylation
Large organized chromatin lysine domains
Partially methylated domains
Tumor
Online Access:https://doi.org/10.1186/s13072-025-00570-0
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