TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus

TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus

The cGAS-STING signaling pathway serves as a pivotal surveillance mechanism for cytosolic double-stranded DNA (dsDNA) detection in mammalian systems. While STING-mediated type I interferon production is crucial for host defense, sustained activation of this pathway contributes to autoimmune patholog...

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Bibliographic Details
Main Authors: Li Chen, Ma Ang, Bai Yu, Liu Zitao, Tian Linghan, Wang Ziyuan, Ma Huaishun, Chen Zhengpu, Gao Zhengheng, Feng Shijie, Fu Ping
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-03-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
systemic lupus erythematosus
cGAS-STING signaling
autophagy
ubiquitylation
TRIM21
p62/SQSTM1
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2025046
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