Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection
ABSTRACT Neutrophil extrusion of neutrophil extracellular traps (NETs) in a process called NETosis provides immune defense against extracellular bacteria. It has been observed that bacteria are capable of activating neutrophils to release NETs that subsequently kill them or at least prevent their lo...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2025-05-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00189-25 |
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| author | Qi Liu Ruke Chen Ziyan Zhang Zhou Sha Haibo Wu |
| author_facet | Qi Liu Ruke Chen Ziyan Zhang Zhou Sha Haibo Wu |
| author_sort | Qi Liu |
| collection | DOAJ |
| description | ABSTRACT Neutrophil extrusion of neutrophil extracellular traps (NETs) in a process called NETosis provides immune defense against extracellular bacteria. It has been observed that bacteria are capable of activating neutrophils to release NETs that subsequently kill them or at least prevent their local spread within host tissue. However, existing studies have mainly focused on the isolated function of NETs, with less attention given to their anti-bacterial mechanisms through interactions with other immune cell populations. The net effect of these complex intercellular interactions, which may act additively, synergistically, or antagonistically, is a critical determinant in the outcomes of host–pathogen interactions. This review summarizes the mechanisms underlying classic NET formation and their crosstalk with the immune system, offering novel insights aimed at balancing the anti-microbial function with their potential inflammatory risks. |
| format | Article |
| id | doaj-art-38c4f41e0c24464bbaf26ef77d1b6de6 |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-38c4f41e0c24464bbaf26ef77d1b6de62025-08-20T02:25:02ZengAmerican Society for MicrobiologymBio2150-75112025-05-0116510.1128/mbio.00189-25Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infectionQi Liu0Ruke Chen1Ziyan Zhang2Zhou Sha3Haibo Wu4School of Life Sciences, Chongqing University, Chongqing, ChinaSchool of Life Sciences, Chongqing University, Chongqing, ChinaSchool of Life Sciences, Chongqing University, Chongqing, ChinaSchool of Life Sciences, Chongqing University, Chongqing, ChinaSchool of Life Sciences, Chongqing University, Chongqing, ChinaABSTRACT Neutrophil extrusion of neutrophil extracellular traps (NETs) in a process called NETosis provides immune defense against extracellular bacteria. It has been observed that bacteria are capable of activating neutrophils to release NETs that subsequently kill them or at least prevent their local spread within host tissue. However, existing studies have mainly focused on the isolated function of NETs, with less attention given to their anti-bacterial mechanisms through interactions with other immune cell populations. The net effect of these complex intercellular interactions, which may act additively, synergistically, or antagonistically, is a critical determinant in the outcomes of host–pathogen interactions. This review summarizes the mechanisms underlying classic NET formation and their crosstalk with the immune system, offering novel insights aimed at balancing the anti-microbial function with their potential inflammatory risks.https://journals.asm.org/doi/10.1128/mbio.00189-25neutrophil extracellular traps (NETs)bacterial infectionevasionneutrophilinnate immunityadaptive immunity |
| spellingShingle | Qi Liu Ruke Chen Ziyan Zhang Zhou Sha Haibo Wu Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection mBio neutrophil extracellular traps (NETs) bacterial infection evasion neutrophil innate immunity adaptive immunity |
| title | Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection |
| title_full | Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection |
| title_fullStr | Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection |
| title_full_unstemmed | Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection |
| title_short | Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection |
| title_sort | mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection |
| topic | neutrophil extracellular traps (NETs) bacterial infection evasion neutrophil innate immunity adaptive immunity |
| url | https://journals.asm.org/doi/10.1128/mbio.00189-25 |
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