Testosterone Replacement Therapy in the Treatment of Depression
# Background Depression is a common disorder that affects millions globally and is linked to reduced quality of life and mortality. Its pathophysiology is complex and there are several forms of treatment proposed in the literature with differing side effect profiles. Many patients do not respond to...
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| Format: | Article |
| Language: | English |
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Open Medical Publishing
2022-11-01
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| Series: | Health Psychology Research |
| Online Access: | https://doi.org/10.52965/001c.38956 |
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| author | Danyon J. Anderson Parsia Vazirnia Catherine Loehr Whitney Sternfels Jamal Hasoon Omar Viswanath Alan D. Kaye Ivan Urits |
| author_facet | Danyon J. Anderson Parsia Vazirnia Catherine Loehr Whitney Sternfels Jamal Hasoon Omar Viswanath Alan D. Kaye Ivan Urits |
| author_sort | Danyon J. Anderson |
| collection | DOAJ |
| description | # Background
Depression is a common disorder that affects millions globally and is linked to reduced quality of life and mortality. Its pathophysiology is complex and there are several forms of treatment proposed in the literature with differing side effect profiles. Many patients do not respond to treatment which warrants augmentation with other treatments and the investigation of novel treatments. One of these treatments includes testosterone therapy which evidence suggests might improve depressed mood in older patients with low levels of testosterone and helps restore physical impairments caused by age-related hormonal changes.
# Objective
The objective of this review is to synthesize information regarding clinical depression, its treatment options, and the efficacy and safety of testosterone treatment for the treatment of depression.
# Methods
This review utilized comprehensive secondary and tertiary data analysis across many academic databases and published work pertaining to the topic of interest.
# Results
Within some subpopulations such as men with dysthymic disorder, treatment resistant depression, or low testosterone levels, testosterone administration yielded positive results in the treatment of depression. Additionally, rodent models have shown that administering testosterone to gonadectomized male animals reduces symptoms of depression. Conversely, some studies have found no difference in depressive symptoms after treatment with testosterone when compared with placebo. It was also noted that over administration of testosterone is associated with multiple adverse effects and complications.
# Conclusion
The current evidence provides mixed conclusions on the effectiveness of testosterone therapy for treating depression. More research is needed in adult men to see if declining testosterone levels directly influence the development of depression. |
| format | Article |
| id | doaj-art-38bf697a7a894fa6ae5311ba8b67a428 |
| institution | Kabale University |
| issn | 2420-8124 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Health Psychology Research |
| spelling | doaj-art-38bf697a7a894fa6ae5311ba8b67a4282025-02-11T20:30:29ZengOpen Medical PublishingHealth Psychology Research2420-81242022-11-01104Testosterone Replacement Therapy in the Treatment of DepressionDanyon J. AndersonParsia VazirniaCatherine LoehrWhitney SternfelsJamal HasoonOmar ViswanathAlan D. KayeIvan Urits# Background Depression is a common disorder that affects millions globally and is linked to reduced quality of life and mortality. Its pathophysiology is complex and there are several forms of treatment proposed in the literature with differing side effect profiles. Many patients do not respond to treatment which warrants augmentation with other treatments and the investigation of novel treatments. One of these treatments includes testosterone therapy which evidence suggests might improve depressed mood in older patients with low levels of testosterone and helps restore physical impairments caused by age-related hormonal changes. # Objective The objective of this review is to synthesize information regarding clinical depression, its treatment options, and the efficacy and safety of testosterone treatment for the treatment of depression. # Methods This review utilized comprehensive secondary and tertiary data analysis across many academic databases and published work pertaining to the topic of interest. # Results Within some subpopulations such as men with dysthymic disorder, treatment resistant depression, or low testosterone levels, testosterone administration yielded positive results in the treatment of depression. Additionally, rodent models have shown that administering testosterone to gonadectomized male animals reduces symptoms of depression. Conversely, some studies have found no difference in depressive symptoms after treatment with testosterone when compared with placebo. It was also noted that over administration of testosterone is associated with multiple adverse effects and complications. # Conclusion The current evidence provides mixed conclusions on the effectiveness of testosterone therapy for treating depression. More research is needed in adult men to see if declining testosterone levels directly influence the development of depression.https://doi.org/10.52965/001c.38956 |
| spellingShingle | Danyon J. Anderson Parsia Vazirnia Catherine Loehr Whitney Sternfels Jamal Hasoon Omar Viswanath Alan D. Kaye Ivan Urits Testosterone Replacement Therapy in the Treatment of Depression Health Psychology Research |
| title | Testosterone Replacement Therapy in the Treatment of Depression |
| title_full | Testosterone Replacement Therapy in the Treatment of Depression |
| title_fullStr | Testosterone Replacement Therapy in the Treatment of Depression |
| title_full_unstemmed | Testosterone Replacement Therapy in the Treatment of Depression |
| title_short | Testosterone Replacement Therapy in the Treatment of Depression |
| title_sort | testosterone replacement therapy in the treatment of depression |
| url | https://doi.org/10.52965/001c.38956 |
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