Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia
Introduction: Cytomegalovirus (CMV) DNAemia has been described in critically ill patients, including patients with severe acute respiratory syndrome-coronavirus2 (SARS-CoV-2) infection. Our objective is to evaluate the prevalence and clinical impact of CMV DNAemia among patients undergoing invasive...
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2025-01-01
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| author | Jean-Baptiste Mesland Christine Collienne Virginie Montiel Alexis Werion Philippe Hantson Xavier Wittebole Pierre-François Laterre Ludovic Gerard |
| author_facet | Jean-Baptiste Mesland Christine Collienne Virginie Montiel Alexis Werion Philippe Hantson Xavier Wittebole Pierre-François Laterre Ludovic Gerard |
| author_sort | Jean-Baptiste Mesland |
| collection | DOAJ |
| description | Introduction: Cytomegalovirus (CMV) DNAemia has been described in critically ill patients, including patients with severe acute respiratory syndrome-coronavirus2 (SARS-CoV-2) infection. Our objective is to evaluate the prevalence and clinical impact of CMV DNAemia among patients undergoing invasive mechanical ventilation (IMV) for severe SARS-CoV-2 infection and to explore the association between CMV DNAemia levels and clinical outcomes. Methods: In this retrospective monocentric study, we included patients admitted in a tertiary ICU for severe COVID-19 and who required IMV. We aimed to compare clinical and demographic variables between patients with and without CMV DNAemia. Univariate and Cox regression analyses were performed to identify factors associated with CMV DNAemia. Results: During the study period, CMV blood DNAemia occurred in 30/135 patients (22%). Patients with CMV blood DNAemia had longer ICU and hospital length of stay, as well as longer duration of IMV, and were more likely to have received dexamethasone. However, there was no significant difference in ICU mortality between patients with and without CMV DNAemia (64.8% vs. 56.7%, <i>p</i> = 0.42). The Cox regression analysis showed that dexamethasone was the only factor independently associated with CMV blood DNAemia (HR 4.23 [1.006–17.792], <i>p</i> = 0.049). Conclusions: In patients with severe SARS-CoV-2 pneumonia requiring IMV, CMV DNAemia is common and associated with prolonged ventilation and increased LOS but not with increased mortality. |
| format | Article |
| id | doaj-art-38bd49bbbb2f4de6ac9dd4f8e9b55fd2 |
| institution | DOAJ |
| issn | 2036-7449 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Infectious Disease Reports |
| spelling | doaj-art-38bd49bbbb2f4de6ac9dd4f8e9b55fd22025-08-20T02:44:35ZengMDPI AGInfectious Disease Reports2036-74492025-01-01171810.3390/idr17010008Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 PneumoniaJean-Baptiste Mesland0Christine Collienne1Virginie Montiel2Alexis Werion3Philippe Hantson4Xavier Wittebole5Pierre-François Laterre6Ludovic Gerard7Critical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumCritical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumCritical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumCritical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumCritical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumCritical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumDepartment of Critical Care Medicine, CHR Mons-Hainaut, 7000 Mons, BelgiumCritical Care Department, Cliniques Universitaires Saint-Luc, Université Catolique de Louvain, 1200 Brussels, BelgiumIntroduction: Cytomegalovirus (CMV) DNAemia has been described in critically ill patients, including patients with severe acute respiratory syndrome-coronavirus2 (SARS-CoV-2) infection. Our objective is to evaluate the prevalence and clinical impact of CMV DNAemia among patients undergoing invasive mechanical ventilation (IMV) for severe SARS-CoV-2 infection and to explore the association between CMV DNAemia levels and clinical outcomes. Methods: In this retrospective monocentric study, we included patients admitted in a tertiary ICU for severe COVID-19 and who required IMV. We aimed to compare clinical and demographic variables between patients with and without CMV DNAemia. Univariate and Cox regression analyses were performed to identify factors associated with CMV DNAemia. Results: During the study period, CMV blood DNAemia occurred in 30/135 patients (22%). Patients with CMV blood DNAemia had longer ICU and hospital length of stay, as well as longer duration of IMV, and were more likely to have received dexamethasone. However, there was no significant difference in ICU mortality between patients with and without CMV DNAemia (64.8% vs. 56.7%, <i>p</i> = 0.42). The Cox regression analysis showed that dexamethasone was the only factor independently associated with CMV blood DNAemia (HR 4.23 [1.006–17.792], <i>p</i> = 0.049). Conclusions: In patients with severe SARS-CoV-2 pneumonia requiring IMV, CMV DNAemia is common and associated with prolonged ventilation and increased LOS but not with increased mortality.https://www.mdpi.com/2036-7449/17/1/8COVID-19SARS-CoV-2cytomegalovirusCMVmechanical ventilation |
| spellingShingle | Jean-Baptiste Mesland Christine Collienne Virginie Montiel Alexis Werion Philippe Hantson Xavier Wittebole Pierre-François Laterre Ludovic Gerard Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia Infectious Disease Reports COVID-19 SARS-CoV-2 cytomegalovirus CMV mechanical ventilation |
| title | Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia |
| title_full | Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia |
| title_fullStr | Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia |
| title_full_unstemmed | Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia |
| title_short | Cytomegalovirus Blood DNAemia in Patients with Severe SARS-CoV-2 Pneumonia |
| title_sort | cytomegalovirus blood dnaemia in patients with severe sars cov 2 pneumonia |
| topic | COVID-19 SARS-CoV-2 cytomegalovirus CMV mechanical ventilation |
| url | https://www.mdpi.com/2036-7449/17/1/8 |
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