Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma
Po-Yi Chen,1,2 Chih-Kai Chang,3 Bang-Bin Chen,3 Chih-Hung Hsu,1,2,4 Ann-Lii Cheng,1,2,4 Yu-Yun Shao1,2,4 1Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan; 2Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Medical Ima...
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Dove Medical Press
2025-06-01
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| Series: | Journal of Hepatocellular Carcinoma |
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| author | Chen PY Chang CK Chen BB Hsu CH Cheng AL Shao YY |
| author_facet | Chen PY Chang CK Chen BB Hsu CH Cheng AL Shao YY |
| author_sort | Chen PY |
| collection | DOAJ |
| description | Po-Yi Chen,1,2 Chih-Kai Chang,3 Bang-Bin Chen,3 Chih-Hung Hsu,1,2,4 Ann-Lii Cheng,1,2,4 Yu-Yun Shao1,2,4 1Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan; 2Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 4Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, TaiwanCorrespondence: Yu-Yun Shao, Department of Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, 10002, Taiwan, Tel +886 2 23123456 ext. 266008, Fax +886 2 23711174, Email yuyunshao@gmail.comPurpose: Outcomes in the treatment of unresectable infiltrative hepatocellular carcinoma (HCC) are poorly understood, and infiltrative HCC is generally underrepresented in clinical trials. The present study explored outcomes associated with the treatment of infiltrative HCC with various systemic therapies.Patients and Methods: We enrolled all patients with Barcelona Clinic Liver Cancer stage C infiltrative or multinodular HCC who received first-line systemic therapy between January 2015 and December 2021 at a single center. We compared baseline characteristics and treatment outcomes for the two HCC subtypes.Results: In total, 260 patients were enrolled, 128 (49.2%) of whom had infiltrative HCC. Patients with infiltrative HCC were more likely to have macrovascular invasion (91.4% vs 68.2%, p < 0.001) but less likely to have extrahepatic spread (32.0% vs 54.5%, p < 0.001) than patients with multinodular HCC. In patients who received multikinase inhibitors alone, the time to treatment failure (TTF) and overall survival (OS) were similar for the 2 HCC subtypes. In patients who received immune checkpoint inhibitor (ICI)-based therapy, multivariate analyses revealed that infiltrative HCC was associated with shorter TTF (HR: 4.07, 95% CI: 2.13– 7.79, p < 0.001) and poorer OS (HR: 3.27, 95% CI: 1.76– 6.11, p < 0.001).Conclusion: In patients receiving ICI-based therapy for HCC, infiltrative HCC was associated with poorer outcomes.Keywords: hepatocellular carcinoma, HCC, infiltrative, systemic therapy, multikinase inhibitor, immune checkpoint-inhibitor |
| format | Article |
| id | doaj-art-38bd2a4ab0bc43d1822b8219bfcef852 |
| institution | Kabale University |
| issn | 2253-5969 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj-art-38bd2a4ab0bc43d1822b8219bfcef8522025-08-20T03:32:37ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692025-06-01Volume 12Issue 112211229104115Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular CarcinomaChen PY0Chang CK1Chen BB2Hsu CH3Cheng AL4Shao YY5Medical OncologyDepartment of Medical ImagingDepartment of Medical ImagingDepartment of OncologyDepartment of Oncology; Department of Medical OncologyDepartment of OncologyPo-Yi Chen,1,2 Chih-Kai Chang,3 Bang-Bin Chen,3 Chih-Hung Hsu,1,2,4 Ann-Lii Cheng,1,2,4 Yu-Yun Shao1,2,4 1Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan; 2Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 4Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, TaiwanCorrespondence: Yu-Yun Shao, Department of Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, 10002, Taiwan, Tel +886 2 23123456 ext. 266008, Fax +886 2 23711174, Email yuyunshao@gmail.comPurpose: Outcomes in the treatment of unresectable infiltrative hepatocellular carcinoma (HCC) are poorly understood, and infiltrative HCC is generally underrepresented in clinical trials. The present study explored outcomes associated with the treatment of infiltrative HCC with various systemic therapies.Patients and Methods: We enrolled all patients with Barcelona Clinic Liver Cancer stage C infiltrative or multinodular HCC who received first-line systemic therapy between January 2015 and December 2021 at a single center. We compared baseline characteristics and treatment outcomes for the two HCC subtypes.Results: In total, 260 patients were enrolled, 128 (49.2%) of whom had infiltrative HCC. Patients with infiltrative HCC were more likely to have macrovascular invasion (91.4% vs 68.2%, p < 0.001) but less likely to have extrahepatic spread (32.0% vs 54.5%, p < 0.001) than patients with multinodular HCC. In patients who received multikinase inhibitors alone, the time to treatment failure (TTF) and overall survival (OS) were similar for the 2 HCC subtypes. In patients who received immune checkpoint inhibitor (ICI)-based therapy, multivariate analyses revealed that infiltrative HCC was associated with shorter TTF (HR: 4.07, 95% CI: 2.13– 7.79, p < 0.001) and poorer OS (HR: 3.27, 95% CI: 1.76– 6.11, p < 0.001).Conclusion: In patients receiving ICI-based therapy for HCC, infiltrative HCC was associated with poorer outcomes.Keywords: hepatocellular carcinoma, HCC, infiltrative, systemic therapy, multikinase inhibitor, immune checkpoint-inhibitorhttps://www.dovepress.com/treatment-outcomes-of-systemic-therapies-for-infiltrative-hepatocellul-peer-reviewed-fulltext-article-JHChepatocellular carcinomainfiltrativesystemic therapymultikinase inhibitorimmune checkpoint-inhibitor |
| spellingShingle | Chen PY Chang CK Chen BB Hsu CH Cheng AL Shao YY Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma Journal of Hepatocellular Carcinoma hepatocellular carcinoma infiltrative systemic therapy multikinase inhibitor immune checkpoint-inhibitor |
| title | Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma |
| title_full | Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma |
| title_fullStr | Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma |
| title_full_unstemmed | Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma |
| title_short | Treatment Outcomes of Systemic Therapies for Infiltrative Hepatocellular Carcinoma |
| title_sort | treatment outcomes of systemic therapies for infiltrative hepatocellular carcinoma |
| topic | hepatocellular carcinoma infiltrative systemic therapy multikinase inhibitor immune checkpoint-inhibitor |
| url | https://www.dovepress.com/treatment-outcomes-of-systemic-therapies-for-infiltrative-hepatocellul-peer-reviewed-fulltext-article-JHC |
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