Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug suscept...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/31/5/24-1123_article |
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| _version_ | 1850171853446840320 |
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| author | Emi Takashita Hiroko Morita Shiho Nagata Seiichiro Fujisaki Hideka Miura Tatsuya Ikeda Kenichi Komabayashi Mika Sasaki Yohei Matoba Tomoko Takahashi Naomi Ogawa Katsumi Mizuta Sueshi Ito Noriko Kishida Kazuya Nakamura Masayuki Shirakura Shinji Watanabe Hideki Hasegawa |
| author_facet | Emi Takashita Hiroko Morita Shiho Nagata Seiichiro Fujisaki Hideka Miura Tatsuya Ikeda Kenichi Komabayashi Mika Sasaki Yohei Matoba Tomoko Takahashi Naomi Ogawa Katsumi Mizuta Sueshi Ito Noriko Kishida Kazuya Nakamura Masayuki Shirakura Shinji Watanabe Hideki Hasegawa |
| author_sort | Emi Takashita |
| collection | DOAJ |
| description |
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.
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| format | Article |
| id | doaj-art-38bcdbd8580f4dfe97e44b738c3fd7c6 |
| institution | OA Journals |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-38bcdbd8580f4dfe97e44b738c3fd7c62025-08-20T02:20:12ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-05-013151019102310.3201/eid3105.241123Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024Emi TakashitaHiroko MoritaShiho NagataSeiichiro FujisakiHideka MiuraTatsuya IkedaKenichi KomabayashiMika SasakiYohei MatobaTomoko TakahashiNaomi OgawaKatsumi MizutaSueshi ItoNoriko KishidaKazuya NakamuraMasayuki ShirakuraShinji WatanabeHideki Hasegawa Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations. https://wwwnc.cdc.gov/eid/article/31/5/24-1123_articleinfluenza virusinfluenzavirusescap-dependent endonuclease inhibitorbaloxavir marboxilbaloxavir acid |
| spellingShingle | Emi Takashita Hiroko Morita Shiho Nagata Seiichiro Fujisaki Hideka Miura Tatsuya Ikeda Kenichi Komabayashi Mika Sasaki Yohei Matoba Tomoko Takahashi Naomi Ogawa Katsumi Mizuta Sueshi Ito Noriko Kishida Kazuya Nakamura Masayuki Shirakura Shinji Watanabe Hideki Hasegawa Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 Emerging Infectious Diseases influenza virus influenza viruses cap-dependent endonuclease inhibitor baloxavir marboxil baloxavir acid |
| title | Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 |
| title_full | Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 |
| title_fullStr | Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 |
| title_full_unstemmed | Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 |
| title_short | Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024 |
| title_sort | influenza a h1n1 pdm09 virus with reduced susceptibility to baloxavir japan 2024 |
| topic | influenza virus influenza viruses cap-dependent endonuclease inhibitor baloxavir marboxil baloxavir acid |
| url | https://wwwnc.cdc.gov/eid/article/31/5/24-1123_article |
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