Osmotic Demyelinating Syndrome
ABSTRACT. This article discusses the clinical cases of rare and difficult to diagnose brain damage — osmotic demyelinating syndrome (ODS). ODS is a lifethreatening condition, manifested by acute demyelination of the headbrain on the background of water-electrolyte disturbances,usually associated wit...
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2020-10-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/916 |
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| author | G. R. Ramazanov E. V. Shevchenko E. A. Kovaleva I. G. Zhelev V. N. Stepanov S. Z. Shakhpazov K. V. Korigova S. S. Petrikov |
| author_facet | G. R. Ramazanov E. V. Shevchenko E. A. Kovaleva I. G. Zhelev V. N. Stepanov S. Z. Shakhpazov K. V. Korigova S. S. Petrikov |
| author_sort | G. R. Ramazanov |
| collection | DOAJ |
| description | ABSTRACT. This article discusses the clinical cases of rare and difficult to diagnose brain damage — osmotic demyelinating syndrome (ODS). ODS is a lifethreatening condition, manifested by acute demyelination of the headbrain on the background of water-electrolyte disturbances,usually associated with fast management of hyponatremia. Within the framework of ODS, central pontine myelinolysis (CPM) and extra-pontine myelinolysis (EPM) are observed, which are accompanied by acute demyelination in the pons and white matter of the cerebral hemispheres, respectively. In 60%, CPM combine with EPM. The main reason for the development of ODS is a violation of water-electrolyte metabolism associated with alcohol abuse, chronic hepatic and/or renal failure, diabetes mellitus, Sheehan syndrome, polydipsia, condition after the removal of pituitary adenoma, bulimia, immunodeficiency syndrome. Today, the diagnosis of ODS is based on magnetic resonance imaging of the brain. The article indicates the main causes of the disease, clinical features, methods of diagnosis and treatment, as well as the outcomes of the disease. |
| format | Article |
| id | doaj-art-38bbe01c4edc4e659299c127cfdebd97 |
| institution | DOAJ |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2020-10-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-38bbe01c4edc4e659299c127cfdebd972025-08-20T02:59:28ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172020-10-019115916610.23934/2223-9022-2020-9-1-159-166584Osmotic Demyelinating SyndromeG. R. Ramazanov0E. V. Shevchenko1E. A. Kovaleva2I. G. Zhelev3V. N. Stepanov4S. Z. Shakhpazov5K. V. Korigova6S. S. Petrikov7Department for Patients with Acute Cerebrovascular Accident with Intensive Care Unit, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentDepartment for Patients with Acute Cerebrovascular Accident with Intensive Care Unit, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentDepartment for Patients with Acute Cerebrovascular Accident with Intensive Care Unit, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentDepartment for Patients with Acute Cerebrovascular Accident with Intensive Care Unit, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentDepartment for Patients with Acute Cerebrovascular Accident with Intensive Care Unit, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentN.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentABSTRACT. This article discusses the clinical cases of rare and difficult to diagnose brain damage — osmotic demyelinating syndrome (ODS). ODS is a lifethreatening condition, manifested by acute demyelination of the headbrain on the background of water-electrolyte disturbances,usually associated with fast management of hyponatremia. Within the framework of ODS, central pontine myelinolysis (CPM) and extra-pontine myelinolysis (EPM) are observed, which are accompanied by acute demyelination in the pons and white matter of the cerebral hemispheres, respectively. In 60%, CPM combine with EPM. The main reason for the development of ODS is a violation of water-electrolyte metabolism associated with alcohol abuse, chronic hepatic and/or renal failure, diabetes mellitus, Sheehan syndrome, polydipsia, condition after the removal of pituitary adenoma, bulimia, immunodeficiency syndrome. Today, the diagnosis of ODS is based on magnetic resonance imaging of the brain. The article indicates the main causes of the disease, clinical features, methods of diagnosis and treatment, as well as the outcomes of the disease.https://www.jnmp.ru/jour/article/view/916central pontine myelinolysisextrapontine myelinolysisosmotic demyelinating syndrome |
| spellingShingle | G. R. Ramazanov E. V. Shevchenko E. A. Kovaleva I. G. Zhelev V. N. Stepanov S. Z. Shakhpazov K. V. Korigova S. S. Petrikov Osmotic Demyelinating Syndrome Неотложная медицинская помощь central pontine myelinolysis extrapontine myelinolysis osmotic demyelinating syndrome |
| title | Osmotic Demyelinating Syndrome |
| title_full | Osmotic Demyelinating Syndrome |
| title_fullStr | Osmotic Demyelinating Syndrome |
| title_full_unstemmed | Osmotic Demyelinating Syndrome |
| title_short | Osmotic Demyelinating Syndrome |
| title_sort | osmotic demyelinating syndrome |
| topic | central pontine myelinolysis extrapontine myelinolysis osmotic demyelinating syndrome |
| url | https://www.jnmp.ru/jour/article/view/916 |
| work_keys_str_mv | AT grramazanov osmoticdemyelinatingsyndrome AT evshevchenko osmoticdemyelinatingsyndrome AT eakovaleva osmoticdemyelinatingsyndrome AT igzhelev osmoticdemyelinatingsyndrome AT vnstepanov osmoticdemyelinatingsyndrome AT szshakhpazov osmoticdemyelinatingsyndrome AT kvkorigova osmoticdemyelinatingsyndrome AT sspetrikov osmoticdemyelinatingsyndrome |