Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation
The aim of this work is to study morphometric characteristics and distribution of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation. Materials and methods. We studied the distribution and quantitative changes of CD56-positive cells in guinea pig lung in...
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Zaporizhzhia State Medical and Pharmaceutical University
2022-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/235880/250046 |
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| author | S. S. Popko V. M. Yevtushenko H. A. Zidrashko |
| author_facet | S. S. Popko V. M. Yevtushenko H. A. Zidrashko |
| author_sort | S. S. Popko |
| collection | DOAJ |
| description | The aim of this work is to study morphometric characteristics and distribution of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation.
Materials and methods. We studied the distribution and quantitative changes of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation using histological, histochemical, immunohistochemical, morphometric and statistical methods.
Results. The number of CD56-positive cells increased in the dynamics of experimental ovalbumin-induced allergic inflammation. The increase in the mean number of CD56-positive cells was found in the early period of allergic inflammation (on the 30th day, experimental group II) by 64.5 % (P*/** < 0.001) compared to the control group and by 56.4 % (P* < 0.01) compared to the 23rd day of examinations (experimental group I). The following increase in the mean number of CD56-positive cells by 60.2 % (P*/** < 0.001) was detected in group III compared to the 23rd day of the experiment (group I). However, the mean number of CD56-positive cells was shown to be decreased by 51.5 % (P*/** < 0.001) in group IV compared to the 36th experimental day (group III).
Conclusions. CD56-positive cells are located in the pulmonary interstitium. The number of CD56-positive cells is statistically significantly increased in group III in the late stages of the allergic inflammation indicating an active involvement of these cells in maintaining allergen-induced airway inflammation.
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| format | Article |
| id | doaj-art-38ba386b8a3240a79ef6fc9ae208d548 |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-38ba386b8a3240a79ef6fc9ae208d5482025-08-20T03:18:31ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102022-02-01241798310.14739/2310-1210.2022.1.235880Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammationS. S. Popko0https://orcid.org/0000-0002-5533-4556V. M. Yevtushenko1https://orcid.org/0000-0002-6858-6488H. A. Zidrashko2Zaporizhzhia State Medical University, UkraineZaporizhzhia State Medical University, UkraineZaporizhzhia State Medical University, UkraineThe aim of this work is to study morphometric characteristics and distribution of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation. Materials and methods. We studied the distribution and quantitative changes of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation using histological, histochemical, immunohistochemical, morphometric and statistical methods. Results. The number of CD56-positive cells increased in the dynamics of experimental ovalbumin-induced allergic inflammation. The increase in the mean number of CD56-positive cells was found in the early period of allergic inflammation (on the 30th day, experimental group II) by 64.5 % (P*/** < 0.001) compared to the control group and by 56.4 % (P* < 0.01) compared to the 23rd day of examinations (experimental group I). The following increase in the mean number of CD56-positive cells by 60.2 % (P*/** < 0.001) was detected in group III compared to the 23rd day of the experiment (group I). However, the mean number of CD56-positive cells was shown to be decreased by 51.5 % (P*/** < 0.001) in group IV compared to the 36th experimental day (group III). Conclusions. CD56-positive cells are located in the pulmonary interstitium. The number of CD56-positive cells is statistically significantly increased in group III in the late stages of the allergic inflammation indicating an active involvement of these cells in maintaining allergen-induced airway inflammation. http://zmj.zsmu.edu.ua/article/view/235880/250046cd56-positive celllungguinea pigsallergyimmunohistochemical stainingneuroendocrine cells |
| spellingShingle | S. S. Popko V. M. Yevtushenko H. A. Zidrashko Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation Zaporožskij Medicinskij Žurnal cd56-positive cell lung guinea pigs allergy immunohistochemical staining neuroendocrine cells |
| title | Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation |
| title_full | Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation |
| title_fullStr | Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation |
| title_full_unstemmed | Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation |
| title_short | Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation |
| title_sort | characteristics of cd56 positive cells in guinea pig lung in the dynamics of experimental allergic inflammation |
| topic | cd56-positive cell lung guinea pigs allergy immunohistochemical staining neuroendocrine cells |
| url | http://zmj.zsmu.edu.ua/article/view/235880/250046 |
| work_keys_str_mv | AT sspopko characteristicsofcd56positivecellsinguineapiglunginthedynamicsofexperimentalallergicinflammation AT vmyevtushenko characteristicsofcd56positivecellsinguineapiglunginthedynamicsofexperimentalallergicinflammation AT hazidrashko characteristicsofcd56positivecellsinguineapiglunginthedynamicsofexperimentalallergicinflammation |