Climate change and ocular health: temperature-pollution synergies amplify uveitis burden
BackgroundUveitis, an inflammatory eye disease, exhibits seasonal patterns, which suggest environmental influences. This study examines the link between average temperature and uveitis outpatient visits, considering air pollution’s modifying effects.MethodsWe analyzed uveitis outpatient data (n = 8,...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1650255/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849714697124708352 |
|---|---|
| author | Yue Tan Yue Tan Yue Tan Yue Yin Yue Yin Yue Yin Boya Lei Boya Lei Boya Lei Min Zhou Min Zhou Min Zhou Zhengyue Gu Jingjing You Tong Lin Tong Lin Tong Lin Lan Gong Lan Gong Lan Gong |
| author_facet | Yue Tan Yue Tan Yue Tan Yue Yin Yue Yin Yue Yin Boya Lei Boya Lei Boya Lei Min Zhou Min Zhou Min Zhou Zhengyue Gu Jingjing You Tong Lin Tong Lin Tong Lin Lan Gong Lan Gong Lan Gong |
| author_sort | Yue Tan |
| collection | DOAJ |
| description | BackgroundUveitis, an inflammatory eye disease, exhibits seasonal patterns, which suggest environmental influences. This study examines the link between average temperature and uveitis outpatient visits, considering air pollution’s modifying effects.MethodsWe analyzed uveitis outpatient data (n = 8,090) from a major hospital in Shanghai between 2017 and 2023, along with meteorological and air pollutant data. A distributed lag non-linear model (DLNM) was used to assess the associations between temperature and outpatient visits, adjusting for humidity, pollutants, and temporal factors.ResultsA non-linear relationship exists between temperature and uveitis visits. Lower temperatures increased visits, with peak relative risk at −4°C lagged by 1 day (RR = 1.351, 95%CI: 1.069–1.706). Significant associations were found at lags 0–1 and 12–14, with the highest risk at lag 14 (−4°C, RR = 1.257, 95%CI: 1.113–1.420). Stratified analyses showed stronger associations in males and individuals under 60 years. High humidity and elevated PM2.5 levels strengthened the cold temperature association, while extremely high temperatures (33–34°C) increased visits under low humidity (RR = 2.625, 95%CI: 1.034–6.668 at 34°C).ConclusionTemperature extremes are linked to increased uveitis outpatient visits in Shanghai, particularly with cold temperatures in high-humidity and high-PM2.5 environments, and hot temperatures under low humidity. |
| format | Article |
| id | doaj-art-38b7d3141d4d45eebadff0f951473322 |
| institution | DOAJ |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-38b7d3141d4d45eebadff0f9514733222025-08-20T03:13:38ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-07-011310.3389/fpubh.2025.16502551650255Climate change and ocular health: temperature-pollution synergies amplify uveitis burdenYue Tan0Yue Tan1Yue Tan2Yue Yin3Yue Yin4Yue Yin5Boya Lei6Boya Lei7Boya Lei8Min Zhou9Min Zhou10Min Zhou11Zhengyue Gu12Jingjing You13Tong Lin14Tong Lin15Tong Lin16Lan Gong17Lan Gong18Lan Gong19Department of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaSchool of Medical Sciences, University of Sydney, Sydney, NSW, AustraliaSchool of Medical Sciences, University of Sydney, Sydney, NSW, AustraliaDepartment of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye Institute, Eye and ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaBackgroundUveitis, an inflammatory eye disease, exhibits seasonal patterns, which suggest environmental influences. This study examines the link between average temperature and uveitis outpatient visits, considering air pollution’s modifying effects.MethodsWe analyzed uveitis outpatient data (n = 8,090) from a major hospital in Shanghai between 2017 and 2023, along with meteorological and air pollutant data. A distributed lag non-linear model (DLNM) was used to assess the associations between temperature and outpatient visits, adjusting for humidity, pollutants, and temporal factors.ResultsA non-linear relationship exists between temperature and uveitis visits. Lower temperatures increased visits, with peak relative risk at −4°C lagged by 1 day (RR = 1.351, 95%CI: 1.069–1.706). Significant associations were found at lags 0–1 and 12–14, with the highest risk at lag 14 (−4°C, RR = 1.257, 95%CI: 1.113–1.420). Stratified analyses showed stronger associations in males and individuals under 60 years. High humidity and elevated PM2.5 levels strengthened the cold temperature association, while extremely high temperatures (33–34°C) increased visits under low humidity (RR = 2.625, 95%CI: 1.034–6.668 at 34°C).ConclusionTemperature extremes are linked to increased uveitis outpatient visits in Shanghai, particularly with cold temperatures in high-humidity and high-PM2.5 environments, and hot temperatures under low humidity.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1650255/fulluveitisoutpatient visitstemperaturedistributed lag nonlinear modelair pollution |
| spellingShingle | Yue Tan Yue Tan Yue Tan Yue Yin Yue Yin Yue Yin Boya Lei Boya Lei Boya Lei Min Zhou Min Zhou Min Zhou Zhengyue Gu Jingjing You Tong Lin Tong Lin Tong Lin Lan Gong Lan Gong Lan Gong Climate change and ocular health: temperature-pollution synergies amplify uveitis burden Frontiers in Public Health uveitis outpatient visits temperature distributed lag nonlinear model air pollution |
| title | Climate change and ocular health: temperature-pollution synergies amplify uveitis burden |
| title_full | Climate change and ocular health: temperature-pollution synergies amplify uveitis burden |
| title_fullStr | Climate change and ocular health: temperature-pollution synergies amplify uveitis burden |
| title_full_unstemmed | Climate change and ocular health: temperature-pollution synergies amplify uveitis burden |
| title_short | Climate change and ocular health: temperature-pollution synergies amplify uveitis burden |
| title_sort | climate change and ocular health temperature pollution synergies amplify uveitis burden |
| topic | uveitis outpatient visits temperature distributed lag nonlinear model air pollution |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1650255/full |
| work_keys_str_mv | AT yuetan climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT yuetan climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT yuetan climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT yueyin climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT yueyin climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT yueyin climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT boyalei climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT boyalei climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT boyalei climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT minzhou climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT minzhou climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT minzhou climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT zhengyuegu climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT jingjingyou climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT tonglin climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT tonglin climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT tonglin climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT langong climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT langong climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden AT langong climatechangeandocularhealthtemperaturepollutionsynergiesamplifyuveitisburden |