Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions
Achieving long-term survival in pig-to-primate liver xenotransplantation has proven highly challenging due to significant hematological issues. This paper investigates the primary obstacles from a hematological perspective, focusing on coagulation disorders caused by molecular incompatibility betwee...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society for Transplantation
2025-03-01
|
| Series: | Clinical Transplantation and Research |
| Subjects: | |
| Online Access: | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0044 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850049349172592640 |
|---|---|
| author | Jae Young Kim |
| author_facet | Jae Young Kim |
| author_sort | Jae Young Kim |
| collection | DOAJ |
| description | Achieving long-term survival in pig-to-primate liver xenotransplantation has proven highly challenging due to significant hematological issues. This paper investigates the primary obstacles from a hematological perspective, focusing on coagulation disorders caused by molecular incompatibility between species. It also examines the mismatched glycan structures on the surfaces of platelets and red blood cells, which lead to sequestration and phagocytosis by recipient macrophages. These mismatches underscore the need for improved glycan and molecular compatibility to overcome immunological and physiological barriers. Moreover, the liver's unique role in synthesizing a wide array of proteins, especially those involved in blood coagulation, introduces additional challenges of molecular incompatibility compared to other organs, such as the heart and kidneys. This study highlights the importance of addressing these challenges to improve the outcomes of liver xenotransplantation and suggests the necessity of strategies like glycan matching and the development of gene-edited pigs specifically tailored for liver transplantation. |
| format | Article |
| id | doaj-art-38b460a0f50240a0a7dfd285a9a10355 |
| institution | DOAJ |
| issn | 3022-6783 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | The Korean Society for Transplantation |
| record_format | Article |
| series | Clinical Transplantation and Research |
| spelling | doaj-art-38b460a0f50240a0a7dfd285a9a103552025-08-20T02:53:44ZengThe Korean Society for TransplantationClinical Transplantation and Research3022-67832025-03-01391122310.4285/ctr.24.0044ctr.24.0044Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directionsJae Young Kim0Department of Life Science, Gachon University, Seongnam, KoreaAchieving long-term survival in pig-to-primate liver xenotransplantation has proven highly challenging due to significant hematological issues. This paper investigates the primary obstacles from a hematological perspective, focusing on coagulation disorders caused by molecular incompatibility between species. It also examines the mismatched glycan structures on the surfaces of platelets and red blood cells, which lead to sequestration and phagocytosis by recipient macrophages. These mismatches underscore the need for improved glycan and molecular compatibility to overcome immunological and physiological barriers. Moreover, the liver's unique role in synthesizing a wide array of proteins, especially those involved in blood coagulation, introduces additional challenges of molecular incompatibility compared to other organs, such as the heart and kidneys. This study highlights the importance of addressing these challenges to improve the outcomes of liver xenotransplantation and suggests the necessity of strategies like glycan matching and the development of gene-edited pigs specifically tailored for liver transplantation.https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0044xenotransplantationliverhematologycoagulationplatelet |
| spellingShingle | Jae Young Kim Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions Clinical Transplantation and Research xenotransplantation liver hematology coagulation platelet |
| title | Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions |
| title_full | Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions |
| title_fullStr | Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions |
| title_full_unstemmed | Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions |
| title_short | Addressing glycan and hematological barriers in pig-to-nonhuman primate liver xenotransplantation: challenges and future directions |
| title_sort | addressing glycan and hematological barriers in pig to nonhuman primate liver xenotransplantation challenges and future directions |
| topic | xenotransplantation liver hematology coagulation platelet |
| url | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0044 |
| work_keys_str_mv | AT jaeyoungkim addressingglycanandhematologicalbarriersinpigtononhumanprimateliverxenotransplantationchallengesandfuturedirections |