Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy
Diabetic retinopathy (DR) is a microvascular complication arising as a secondary effect of diabetes, with both genetic and environmental factors playing a significant role in its onset and progression. Epigenetics serves as the crucial link between these genetic and environmental influences. Among t...
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/575 |
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| author | Yao Lu Yizheng Zhang Jin Yao Wen Bai Keran Li |
| author_facet | Yao Lu Yizheng Zhang Jin Yao Wen Bai Keran Li |
| author_sort | Yao Lu |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is a microvascular complication arising as a secondary effect of diabetes, with both genetic and environmental factors playing a significant role in its onset and progression. Epigenetics serves as the crucial link between these genetic and environmental influences. Among the various epigenetic mechanisms, histone modification stands out as a key regulatory process associated with the development of many diseases. Histone modifications primarily regulate cellular function by influencing gene expression. Modulating histone modifications, particularly through the regulation of enzymes involved in these processes, holds a promising therapeutic approach for managing diseases like DR. In this review, we explore the regulatory mechanisms of histone modification and its contribution to the pathogenesis of DR. |
| format | Article |
| id | doaj-art-38b2b455d90c49dd815e696aefc1ba02 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-38b2b455d90c49dd815e696aefc1ba022025-08-20T02:28:40ZengMDPI AGBiomolecules2218-273X2025-04-0115457510.3390/biom15040575Histone Modifications: Potential Therapeutic Targets for Diabetic RetinopathyYao Lu0Yizheng Zhang1Jin Yao2Wen Bai3Keran Li4Department of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, ChinaThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, ChinaDiabetic retinopathy (DR) is a microvascular complication arising as a secondary effect of diabetes, with both genetic and environmental factors playing a significant role in its onset and progression. Epigenetics serves as the crucial link between these genetic and environmental influences. Among the various epigenetic mechanisms, histone modification stands out as a key regulatory process associated with the development of many diseases. Histone modifications primarily regulate cellular function by influencing gene expression. Modulating histone modifications, particularly through the regulation of enzymes involved in these processes, holds a promising therapeutic approach for managing diseases like DR. In this review, we explore the regulatory mechanisms of histone modification and its contribution to the pathogenesis of DR.https://www.mdpi.com/2218-273X/15/4/575histone modificationdiabetic retinopathyepigeneticepigenetic therapy |
| spellingShingle | Yao Lu Yizheng Zhang Jin Yao Wen Bai Keran Li Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy Biomolecules histone modification diabetic retinopathy epigenetic epigenetic therapy |
| title | Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy |
| title_full | Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy |
| title_fullStr | Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy |
| title_full_unstemmed | Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy |
| title_short | Histone Modifications: Potential Therapeutic Targets for Diabetic Retinopathy |
| title_sort | histone modifications potential therapeutic targets for diabetic retinopathy |
| topic | histone modification diabetic retinopathy epigenetic epigenetic therapy |
| url | https://www.mdpi.com/2218-273X/15/4/575 |
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