Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses
An auditory steady-state response (ASSR) is an electrophysiological response to periodic stimuli that reflects the synchronization of endogenous oscillations. The 40-Hz ASSR is reduced in patients with schizophrenia, bipolar disorder, and autism spectrum disorder, making it a candidate biomarker for...
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Elsevier
2025-04-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925001387 |
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| author | Kentaro Takai Shunsuke Sugiyama Koji Inui Yuka Ikegame Hirohito Yano Jun Shinoda Makoto Nishihara Kazutaka Ohi Toshiki Shioiri |
| author_facet | Kentaro Takai Shunsuke Sugiyama Koji Inui Yuka Ikegame Hirohito Yano Jun Shinoda Makoto Nishihara Kazutaka Ohi Toshiki Shioiri |
| author_sort | Kentaro Takai |
| collection | DOAJ |
| description | An auditory steady-state response (ASSR) is an electrophysiological response to periodic stimuli that reflects the synchronization of endogenous oscillations. The 40-Hz ASSR is reduced in patients with schizophrenia, bipolar disorder, and autism spectrum disorder, making it a candidate biomarker for these psychiatric disorders. Previous studies have revealed that experimental conditions such as stimulus duration and inter-stimulus interval tend to affect ASSR, suggesting that novelty detection may play an important role in determining the magnitude of ASSR. The present study is the first to investigate the effect of novelty detection on 20- and 40-Hz ASSRs in healthy individuals. Magnetoencephalography recordings were obtained from 30 healthy adults exposed to auditory stimuli at 20 and 40 Hz. The stimuli were presented in three paradigms: 20- and 40-Hz repetitive presentations and random presentation, the latter being categorized by whether the preceding stimulus was the same (S trials) or different (D trials). The ASSR amplitude and inter-trial phase coherence (ITPC) were assessed via time-frequency analysis. The results revealed that the 20-Hz ASSR was suppressed with increased novelty, with the highest amplitude and ITPC observed during repetitive presentation. In contrast, the 40-Hz ASSR was enhanced by increased novelty, with the greatest measures observed during the D trials. These findings show that novelty detection modulates 20- and 40-Hz ASSRs in opposite directions, highlighting its critical role in shaping stimulus-induced oscillatory responses. This frequency-specific modulation pattern may provide a novel perspective for understanding ASSR abnormalities in psychiatric disorders. |
| format | Article |
| id | doaj-art-38ac691138ea48b7bb632cba66d5e82e |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-38ac691138ea48b7bb632cba66d5e82e2025-08-20T01:54:11ZengElsevierNeuroImage1095-95722025-04-0131012113610.1016/j.neuroimage.2025.121136Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responsesKentaro Takai0Shunsuke Sugiyama1Koji Inui2Yuka Ikegame3Hirohito Yano4Jun Shinoda5Makoto Nishihara6Kazutaka Ohi7Toshiki Shioiri8Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan; Corresponding author. Shunsuke Sugiyama, Department of Psychiatry, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan; Section of Brain Function Information, National Institute for Physiological Sciences, Okazaki, JapanDepartment of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, JapanDepartment of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, JapanDepartment of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, JapanMultidisciplinary Pain Center, Aichi Medical University, Nagakute, JapanDepartment of Psychiatry, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Psychiatry, Gifu University Graduate School of Medicine, Gifu, JapanAn auditory steady-state response (ASSR) is an electrophysiological response to periodic stimuli that reflects the synchronization of endogenous oscillations. The 40-Hz ASSR is reduced in patients with schizophrenia, bipolar disorder, and autism spectrum disorder, making it a candidate biomarker for these psychiatric disorders. Previous studies have revealed that experimental conditions such as stimulus duration and inter-stimulus interval tend to affect ASSR, suggesting that novelty detection may play an important role in determining the magnitude of ASSR. The present study is the first to investigate the effect of novelty detection on 20- and 40-Hz ASSRs in healthy individuals. Magnetoencephalography recordings were obtained from 30 healthy adults exposed to auditory stimuli at 20 and 40 Hz. The stimuli were presented in three paradigms: 20- and 40-Hz repetitive presentations and random presentation, the latter being categorized by whether the preceding stimulus was the same (S trials) or different (D trials). The ASSR amplitude and inter-trial phase coherence (ITPC) were assessed via time-frequency analysis. The results revealed that the 20-Hz ASSR was suppressed with increased novelty, with the highest amplitude and ITPC observed during repetitive presentation. In contrast, the 40-Hz ASSR was enhanced by increased novelty, with the greatest measures observed during the D trials. These findings show that novelty detection modulates 20- and 40-Hz ASSRs in opposite directions, highlighting its critical role in shaping stimulus-induced oscillatory responses. This frequency-specific modulation pattern may provide a novel perspective for understanding ASSR abnormalities in psychiatric disorders.http://www.sciencedirect.com/science/article/pii/S1053811925001387Auditory steady-state responseNovelty detectionMagnetoencephalographyBeta-band oscillationGamma-band oscillation |
| spellingShingle | Kentaro Takai Shunsuke Sugiyama Koji Inui Yuka Ikegame Hirohito Yano Jun Shinoda Makoto Nishihara Kazutaka Ohi Toshiki Shioiri Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses NeuroImage Auditory steady-state response Novelty detection Magnetoencephalography Beta-band oscillation Gamma-band oscillation |
| title | Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses |
| title_full | Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses |
| title_fullStr | Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses |
| title_full_unstemmed | Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses |
| title_short | Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses |
| title_sort | examining the role of novelty detection in 20 and 40 hz auditory steady state responses |
| topic | Auditory steady-state response Novelty detection Magnetoencephalography Beta-band oscillation Gamma-band oscillation |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925001387 |
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