Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb
Platelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 × 10−6, 7.47 × 10−5 and 7.47 × 10−4 M) increased lymphatic perfusion pressure at the t...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000590 |
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| _version_ | 1832551036999434240 |
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| author | D. E. Dobbins |
| author_facet | D. E. Dobbins |
| author_sort | D. E. Dobbins |
| collection | DOAJ |
| description | Platelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 × 10−6, 7.47 × 10−5 and 7.47 × 10−4 M) increased lymphatic perfusion pressure at the two highest infusion rates. PAF mediated lymphatic constriction was not altered by the intra-arterial infusion of phentolamine but was blocked by the intra-arterial infusion of the PAF receptor antagonist WEB 2170. These data indicate that in addition to PAF's effects on microvascular permeability, this agent may also impact the ability of the lymphatics to transport fluid through alterations in lymphatic smooth muscle tone. PAF mediated lymphatic constriction is not mediated by α-receptors but rather through PAF receptor mediated mechanism. |
| format | Article |
| id | doaj-art-38a808264a524b94a737017af7f7d50e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-38a808264a524b94a737017af7f7d50e2025-02-03T06:05:07ZengWileyMediators of Inflammation0962-93511466-18611992-01-011639139510.1155/S0962935192000590Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimbD. E. Dobbins0Department of Physiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USAPlatelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 × 10−6, 7.47 × 10−5 and 7.47 × 10−4 M) increased lymphatic perfusion pressure at the two highest infusion rates. PAF mediated lymphatic constriction was not altered by the intra-arterial infusion of phentolamine but was blocked by the intra-arterial infusion of the PAF receptor antagonist WEB 2170. These data indicate that in addition to PAF's effects on microvascular permeability, this agent may also impact the ability of the lymphatics to transport fluid through alterations in lymphatic smooth muscle tone. PAF mediated lymphatic constriction is not mediated by α-receptors but rather through PAF receptor mediated mechanism.http://dx.doi.org/10.1155/S0962935192000590 |
| spellingShingle | D. E. Dobbins Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb Mediators of Inflammation |
| title | Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb |
| title_full | Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb |
| title_fullStr | Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb |
| title_full_unstemmed | Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb |
| title_short | Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb |
| title_sort | receptor mechanisms of paf mediated lymphatic constriction in the canine forelimb |
| url | http://dx.doi.org/10.1155/S0962935192000590 |
| work_keys_str_mv | AT dedobbins receptormechanismsofpafmediatedlymphaticconstrictioninthecanineforelimb |