In vitro 3D drug sensitivity testing for patient-derived tumor-like cell clusters and whole-exome sequencing to personalize postoperative treatment: A study protocol for a multicenter randomized controlled trial.

In vitro 3D drug sensitivity testing for patient-derived tumor-like cell clusters and whole-exome sequencing to personalize postoperative treatment: A study protocol for a multicenter randomized controlled trial.

<h4>Background</h4>Colorectal cancer (CRC) ranks as the third most common cancer globally, with significant postoperative recurrence and metastasis rates. The heterogeneity of CRC presents challenges in the selection of adjuvant chemotherapy regimens, highlighting the need for personaliz...

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Main Authors: Xiaoyuan Qiu, Ruiqiang Li, Gengchen Xie, Ning Ning, Zhenjun Wang, Jiaolin Zhou, Ge Liu, Qingchao Tang, Zhuo He, Leilei Yang, Junyang Lu, Peng Li, Guole Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326760
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