Atg5-deficient mesenchymal stem cells protect against non-alcoholic fatty liver by accelerating hepatocyte growth factor secretion

Atg5-deficient mesenchymal stem cells protect against non-alcoholic fatty liver by accelerating hepatocyte growth factor secretion

Abstract Background/aims Mesenchymal stem cells (MSCs) have shown promising therapeutic potential in treating liver diseases, such as non-alcoholic fatty liver disease (NAFLD). Genetic modification has been employed to enhance the characteristics of MSCs for more effective disease treatment. Here, w...

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Bibliographic Details
Main Authors: Caifeng Zhang, Juanjuan Ji, Xuefang Du, Lanfang Zhang, Yaxuan Song, Yuyu Wang, Yanan Jiang, Ke Li, Tingmin Chang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Mesenchymal stem cells
Non-alcoholic fatty liver disease
Atg5
Recycling endosomes
HGF
Online Access:https://doi.org/10.1186/s12964-024-01950-x
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