Immune characterization of lupus nephritis patients undergoing dialysisKey messages
Systemic lupus erythematosus (SLE) activity decreases in some patients with end-stage kidney disease (ESKD). The impact of ESKD on the immune cell profile of SLE patients and lupus activity remains unclear. In this study, we aimed at characterizing immunologically inactive and active SLE patients un...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Translational Autoimmunity |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909025000255 |
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| author | Quentin Simon François Gaillard John Tchen Delphine Bachelet Karim Sacré Katell Peoc'h Noémie Jourde-Chiche Eric Daugas Nicolas Charles |
| author_facet | Quentin Simon François Gaillard John Tchen Delphine Bachelet Karim Sacré Katell Peoc'h Noémie Jourde-Chiche Eric Daugas Nicolas Charles |
| author_sort | Quentin Simon |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) activity decreases in some patients with end-stage kidney disease (ESKD). The impact of ESKD on the immune cell profile of SLE patients and lupus activity remains unclear. In this study, we aimed at characterizing immunologically inactive and active SLE patients undergoing dialysis therapy. Based on multi-parametric flow cytometry assays, an extensive immunophenotyping was performed on blood samples from 47 SLE patients undergoing hemodialysis, 10 non-dialyzed SLE patients with active lupus nephritis (aLN), 6 non-dialyzed patients with a history of LN currently in remission (rLN), and 20 healthy volunteers (HV) as controls (ClinicalTrials.gov Identifier: NCT03921398). The hemodialysis group was composed of 16 SLE patients with inactive disease (iHD), 22 with sustained low disease activity with a non-renal SLEDAI ≤4 (aHD≤4), and 9 highly active SLE patients (aHD>4). A factorial discriminant analysis was performed to validate the association between immune cell signatures and lupus activity. By compiling 12 cellular variables, we describe immune profiles related to highly active SLE patients or associated with both inactive and low-disease activity groups. As non-dialyzed active SLE patients, active patients undergoing hemodialysis showed a specific combination of increased numbers of circulating CD19hi CD27– “atypical naive” B cells, plasmablasts, CD16+ inflammatory monocytes and a basopenia. This study brings a comprehensive overview of immune cell signatures observed in SLE patients undergoing dialysis. We propose a simple immunophenotypic approach for the assessment of lupus activity that may provide help to data-driven personalized medicine in hemodialyzed SLE patients. |
| format | Article |
| id | doaj-art-389c2d50767a4ca9ae63f80aa4c1aa1a |
| institution | Kabale University |
| issn | 2589-9090 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj-art-389c2d50767a4ca9ae63f80aa4c1aa1a2025-08-20T03:26:38ZengElsevierJournal of Translational Autoimmunity2589-90902025-06-011010029010.1016/j.jtauto.2025.100290Immune characterization of lupus nephritis patients undergoing dialysisKey messagesQuentin Simon0François Gaillard1John Tchen2Delphine Bachelet3Karim Sacré4Katell Peoc'h5Noémie Jourde-Chiche6Eric Daugas7Nicolas Charles8Université Paris Cité, Centre de recherche sur l'inflammation, INSERM UMR1149, CNRS EMR8252, Laboratoire d’Excellence Inflamex, Paris, France; Inovarion, Paris, FranceDepartment of Nephrology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, FranceUniversité Paris Cité, Centre de recherche sur l'inflammation, INSERM UMR1149, CNRS EMR8252, Laboratoire d’Excellence Inflamex, Paris, FranceDepartment of Biostatistical Epidemiology and Clinical research, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, INSERM CIC-EC 1425, Paris, FranceUniversité Paris Cité, Centre de recherche sur l'inflammation, INSERM UMR1149, CNRS EMR8252, Laboratoire d’Excellence Inflamex, Paris, France; Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, FranceUniversité Paris Cité, Centre de Recherche sur l’Inflammation, INSERM UMR1149, Laboratoire d'Excellence GR-Ex, Paris, France; Service de Biochimie, Hôpital Bichat, DMU BIOGEM, Assistance Publique-Hôpitaux de Paris, Paris, FranceAix-Marseille Université, C2VN, INSERM, INRAE, Marseille, France; Assistance Publique-Hôpitaux de Marseille, Centre de Néphrologie et Transplantation Rénale, Hôpital de la Conception, Marseille, FranceUniversité Paris Cité, Centre de recherche sur l'inflammation, INSERM UMR1149, CNRS EMR8252, Laboratoire d’Excellence Inflamex, Paris, France; Department of Nephrology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, FranceUniversité Paris Cité, Centre de recherche sur l'inflammation, INSERM UMR1149, CNRS EMR8252, Laboratoire d’Excellence Inflamex, Paris, France; Corresponding author. Centre de recherche sur l'inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Faculté de Médecine Site Bichat, 16 rue Henri Huchard, 75018, Paris, France.Systemic lupus erythematosus (SLE) activity decreases in some patients with end-stage kidney disease (ESKD). The impact of ESKD on the immune cell profile of SLE patients and lupus activity remains unclear. In this study, we aimed at characterizing immunologically inactive and active SLE patients undergoing dialysis therapy. Based on multi-parametric flow cytometry assays, an extensive immunophenotyping was performed on blood samples from 47 SLE patients undergoing hemodialysis, 10 non-dialyzed SLE patients with active lupus nephritis (aLN), 6 non-dialyzed patients with a history of LN currently in remission (rLN), and 20 healthy volunteers (HV) as controls (ClinicalTrials.gov Identifier: NCT03921398). The hemodialysis group was composed of 16 SLE patients with inactive disease (iHD), 22 with sustained low disease activity with a non-renal SLEDAI ≤4 (aHD≤4), and 9 highly active SLE patients (aHD>4). A factorial discriminant analysis was performed to validate the association between immune cell signatures and lupus activity. By compiling 12 cellular variables, we describe immune profiles related to highly active SLE patients or associated with both inactive and low-disease activity groups. As non-dialyzed active SLE patients, active patients undergoing hemodialysis showed a specific combination of increased numbers of circulating CD19hi CD27– “atypical naive” B cells, plasmablasts, CD16+ inflammatory monocytes and a basopenia. This study brings a comprehensive overview of immune cell signatures observed in SLE patients undergoing dialysis. We propose a simple immunophenotypic approach for the assessment of lupus activity that may provide help to data-driven personalized medicine in hemodialyzed SLE patients.http://www.sciencedirect.com/science/article/pii/S2589909025000255Systemic lupus erythematosusLupus nephritisEnd stage kidney diseaseDialysisImmunophenotypingDisease activity |
| spellingShingle | Quentin Simon François Gaillard John Tchen Delphine Bachelet Karim Sacré Katell Peoc'h Noémie Jourde-Chiche Eric Daugas Nicolas Charles Immune characterization of lupus nephritis patients undergoing dialysisKey messages Journal of Translational Autoimmunity Systemic lupus erythematosus Lupus nephritis End stage kidney disease Dialysis Immunophenotyping Disease activity |
| title | Immune characterization of lupus nephritis patients undergoing dialysisKey messages |
| title_full | Immune characterization of lupus nephritis patients undergoing dialysisKey messages |
| title_fullStr | Immune characterization of lupus nephritis patients undergoing dialysisKey messages |
| title_full_unstemmed | Immune characterization of lupus nephritis patients undergoing dialysisKey messages |
| title_short | Immune characterization of lupus nephritis patients undergoing dialysisKey messages |
| title_sort | immune characterization of lupus nephritis patients undergoing dialysiskey messages |
| topic | Systemic lupus erythematosus Lupus nephritis End stage kidney disease Dialysis Immunophenotyping Disease activity |
| url | http://www.sciencedirect.com/science/article/pii/S2589909025000255 |
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