The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats
Background: Diabetic nephropathy (DN) is a common vascular complication of diabetes Miletus (DM) that require weight control and dietary restrictions, especially for protein. A protein-restricted diet with ketoacid analogs (KA) reduces the intake of nitrogen while avoiding the harmful consequences o...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024176384 |
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| author | Ahmed El-Sayed Nour El-Deen Adel shallaby Abdel Kader Ibrahim Mohammed Abdel Aziz Mohammed Ahmad Taha Mohamed Zaeim Hafez Ahmed Muhammad Abdelbaeth Elfiky Ahmed A. Abd El-Rhman Ahmed F. Abdel Ghany Almoatazbellah Mahmoud Elsayed Ahmed Noaman Ali Ali Abdeslam |
| author_facet | Ahmed El-Sayed Nour El-Deen Adel shallaby Abdel Kader Ibrahim Mohammed Abdel Aziz Mohammed Ahmad Taha Mohamed Zaeim Hafez Ahmed Muhammad Abdelbaeth Elfiky Ahmed A. Abd El-Rhman Ahmed F. Abdel Ghany Almoatazbellah Mahmoud Elsayed Ahmed Noaman Ali Ali Abdeslam |
| author_sort | Ahmed El-Sayed Nour El-Deen |
| collection | DOAJ |
| description | Background: Diabetic nephropathy (DN) is a common vascular complication of diabetes Miletus (DM) that require weight control and dietary restrictions, especially for protein. A protein-restricted diet with ketoacid analogs (KA) reduces the intake of nitrogen while avoiding the harmful consequences of inadequate dietary protein intake. Objective: This study aimed to investigate the efficacy and safety of a protein-free diet with ketoacid analogs in chronic kidney disease (CKD)-affected diabetic rats. Material and methods: Sixty adult male albino rats were grouped into six equal groups (G): G (1) Control group, G (2) Normal rats. Received low protein diet, G (3) Diabetic control rats. Received standard diet, G (4) Diabetic rats. Received low protein diet for 12 weeks, G (5) Diabetic received α-keto amino acids (KAA) with a low protein diet and G (6) Diabetic received α-keto amino acids with protein-free diet. Blood sample was used to assess blood glucose (mg/dl), insulin (pmol/L), urea (mg/dl), creatinine (mg/dl), total cholesterol (TC) (mg/dl), LDL (mg/dl), HDL (mg/dl), triglycerides (TG) (mg/dl), and albumin (mg/dl) levels. Results: A significant decrease in blood glucose, serum total cholesterol, LDL, triglycerides, serum urea and creatinine were observed while insulin level, albumin, glomerular filtration rate (GFR), urine volume and HDL were significantly increased in group six. Conclusion: A protein-free diet containing KAA improves renal function, lowers blood glucose levels, maintains body weight, and does not worsen nutritional status in DN over time. |
| format | Article |
| id | doaj-art-3898ba59d2e44deea02af2960beaa53e |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-3898ba59d2e44deea02af2960beaa53e2025-02-02T05:27:53ZengElsevierHeliyon2405-84402025-01-01112e41607The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic ratsAhmed El-Sayed Nour El-Deen0Adel shallaby1Abdel Kader Ibrahim2Mohammed Abdel Aziz Mohammed3Ahmad Taha4Mohamed Zaeim Hafez Ahmed5Muhammad Abdelbaeth Elfiky6Ahmed A. Abd El-Rhman7Ahmed F. Abdel Ghany8Almoatazbellah Mahmoud Elsayed9Ahmed Noaman Ali10Ali Abdeslam11Department of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt; Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan; Corresponding author. Department of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.Department of Physiology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan; Department of physiology, faculty of medicine Port Said University, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan; Department of Pathology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptDepartment of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan; Department of Oral pathology department, Faculty of Dentistry, Tanta University, EgyptDepartment of pharmacology, Faculty of Medicine, Al-Azhar University, Assiut, EgyptBackground: Diabetic nephropathy (DN) is a common vascular complication of diabetes Miletus (DM) that require weight control and dietary restrictions, especially for protein. A protein-restricted diet with ketoacid analogs (KA) reduces the intake of nitrogen while avoiding the harmful consequences of inadequate dietary protein intake. Objective: This study aimed to investigate the efficacy and safety of a protein-free diet with ketoacid analogs in chronic kidney disease (CKD)-affected diabetic rats. Material and methods: Sixty adult male albino rats were grouped into six equal groups (G): G (1) Control group, G (2) Normal rats. Received low protein diet, G (3) Diabetic control rats. Received standard diet, G (4) Diabetic rats. Received low protein diet for 12 weeks, G (5) Diabetic received α-keto amino acids (KAA) with a low protein diet and G (6) Diabetic received α-keto amino acids with protein-free diet. Blood sample was used to assess blood glucose (mg/dl), insulin (pmol/L), urea (mg/dl), creatinine (mg/dl), total cholesterol (TC) (mg/dl), LDL (mg/dl), HDL (mg/dl), triglycerides (TG) (mg/dl), and albumin (mg/dl) levels. Results: A significant decrease in blood glucose, serum total cholesterol, LDL, triglycerides, serum urea and creatinine were observed while insulin level, albumin, glomerular filtration rate (GFR), urine volume and HDL were significantly increased in group six. Conclusion: A protein-free diet containing KAA improves renal function, lowers blood glucose levels, maintains body weight, and does not worsen nutritional status in DN over time.http://www.sciencedirect.com/science/article/pii/S2405844024176384DiabetesKidney diseaseProtein dietKetoacid and protein-free diet |
| spellingShingle | Ahmed El-Sayed Nour El-Deen Adel shallaby Abdel Kader Ibrahim Mohammed Abdel Aziz Mohammed Ahmad Taha Mohamed Zaeim Hafez Ahmed Muhammad Abdelbaeth Elfiky Ahmed A. Abd El-Rhman Ahmed F. Abdel Ghany Almoatazbellah Mahmoud Elsayed Ahmed Noaman Ali Ali Abdeslam The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats Heliyon Diabetes Kidney disease Protein diet Ketoacid and protein-free diet |
| title | The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats |
| title_full | The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats |
| title_fullStr | The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats |
| title_full_unstemmed | The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats |
| title_short | The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats |
| title_sort | safety and efficacy of a protein free diet with ketoacid analogues in chronic kidney disease affected diabetic rats |
| topic | Diabetes Kidney disease Protein diet Ketoacid and protein-free diet |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024176384 |
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