Heterogeneity in Breast Cancer and the Problem of Relevance of Findings
Many attempts are made to identify critical genetic events responsible for the development and progression of breast cancer. There is increasing evidence that breast cancer is a heterogeneous disease, both, phenotypically as well as with respect to its molecular biologically. It is, therefore, extre...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/1999/960923 |
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| _version_ | 1850105804850462720 |
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| author | M. Aubele M. Werner |
| author_facet | M. Aubele M. Werner |
| author_sort | M. Aubele |
| collection | DOAJ |
| description | Many attempts are made to identify critical genetic events responsible for the development and progression of breast cancer. There is increasing evidence that breast cancer is a heterogeneous disease, both, phenotypically as well as with respect to its molecular biologically. It is, therefore, extremely difficult to establish a diagnostically and prognostically relevant tumourigenesis model. Emerging new techniques such as microarrays, will provide us with a wealth of additional data over the next years. The precise sampling of tumour material in clearly defined histopathological lesions will be a prerequisite for the assignment of specific genetic alterations to defined stages of breast disease. |
| format | Article |
| id | doaj-art-389062dcd3894b93b698f576b036ed55 |
| institution | OA Journals |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-389062dcd3894b93b698f576b036ed552025-08-20T02:38:59ZengWileyAnalytical Cellular Pathology0921-89121878-36511999-01-01192535810.1155/1999/960923Heterogeneity in Breast Cancer and the Problem of Relevance of FindingsM. Aubele0M. Werner1GSF – National Research Center for Environment and Health, Institute of Pathology, Neuherberg, GermanyTechnische Universität München, Klinikum rechts der Isar, Institute of Pathology, Munich, GermanyMany attempts are made to identify critical genetic events responsible for the development and progression of breast cancer. There is increasing evidence that breast cancer is a heterogeneous disease, both, phenotypically as well as with respect to its molecular biologically. It is, therefore, extremely difficult to establish a diagnostically and prognostically relevant tumourigenesis model. Emerging new techniques such as microarrays, will provide us with a wealth of additional data over the next years. The precise sampling of tumour material in clearly defined histopathological lesions will be a prerequisite for the assignment of specific genetic alterations to defined stages of breast disease.http://dx.doi.org/10.1155/1999/960923 |
| spellingShingle | M. Aubele M. Werner Heterogeneity in Breast Cancer and the Problem of Relevance of Findings Analytical Cellular Pathology |
| title | Heterogeneity in Breast Cancer and the Problem of Relevance of Findings |
| title_full | Heterogeneity in Breast Cancer and the Problem of Relevance of Findings |
| title_fullStr | Heterogeneity in Breast Cancer and the Problem of Relevance of Findings |
| title_full_unstemmed | Heterogeneity in Breast Cancer and the Problem of Relevance of Findings |
| title_short | Heterogeneity in Breast Cancer and the Problem of Relevance of Findings |
| title_sort | heterogeneity in breast cancer and the problem of relevance of findings |
| url | http://dx.doi.org/10.1155/1999/960923 |
| work_keys_str_mv | AT maubele heterogeneityinbreastcancerandtheproblemofrelevanceoffindings AT mwerner heterogeneityinbreastcancerandtheproblemofrelevanceoffindings |