Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study
Several studies have shown interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic condition that poses challenges in both diagnosis and treatment, is associated with painful pelvic floor muscles (PFM) and altered neural drive to these muscles. However, its pathophysiology could also involve...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/24/23/7417 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849220448705839104 |
|---|---|
| author | Monica Albaladejo-Belmonte Michael Houston Nicholas Dias Theresa Spitznagle Henry Lai Yingchun Zhang Javier Garcia-Casado |
| author_facet | Monica Albaladejo-Belmonte Michael Houston Nicholas Dias Theresa Spitznagle Henry Lai Yingchun Zhang Javier Garcia-Casado |
| author_sort | Monica Albaladejo-Belmonte |
| collection | DOAJ |
| description | Several studies have shown interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic condition that poses challenges in both diagnosis and treatment, is associated with painful pelvic floor muscles (PFM) and altered neural drive to these muscles. However, its pathophysiology could also involve other alterations in the electrical activity of PFM motor units (MUs). Studying these alterations could provide novel insights into IC/BPS and help its clinical management. This study aimed to characterize PFM activity at the MU level in women with IC/BPS and pelvic floor myalgia using high-density surface electromyography (HD-sEMG). Signals were recorded from 15 patients and 15 healthy controls and decomposed into MU action potential (MUAP) spike trains. MUAP amplitude, firing rate, and magnitude-squared coherence between spike trains were compared across groups. Results showed that MUAPs had significantly lower amplitudes during contractions on the patients’ left PFM, and delta-band coherence was significantly higher at rest on their right PFM compared to controls. These findings suggest altered PFM tissue and neuromuscular control in women with IC/BPS and pelvic floor myalgia. Our results demonstrate that HD-sEMG can provide novel insights into IC/BPS-related PFM dysfunction and biomarkers that help identify subgroups of IC/BPS patients, which may aid their diagnosis and treatment. |
| format | Article |
| id | doaj-art-388ed60eeab7484e99b24fc25fe36eca |
| institution | Kabale University |
| issn | 1424-8220 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj-art-388ed60eeab7484e99b24fc25fe36eca2024-12-13T16:31:27ZengMDPI AGSensors1424-82202024-11-012423741710.3390/s24237417Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based StudyMonica Albaladejo-Belmonte0Michael Houston1Nicholas Dias2Theresa Spitznagle3Henry Lai4Yingchun Zhang5Javier Garcia-Casado6Centro de Investigación e Innovación en Bioingeniería (CI2B), Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, SpainDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USADepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USAProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108, USADivision of Urologic Surgery, Departments of Surgery and Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USACentro de Investigación e Innovación en Bioingeniería (CI2B), Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, SpainSeveral studies have shown interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic condition that poses challenges in both diagnosis and treatment, is associated with painful pelvic floor muscles (PFM) and altered neural drive to these muscles. However, its pathophysiology could also involve other alterations in the electrical activity of PFM motor units (MUs). Studying these alterations could provide novel insights into IC/BPS and help its clinical management. This study aimed to characterize PFM activity at the MU level in women with IC/BPS and pelvic floor myalgia using high-density surface electromyography (HD-sEMG). Signals were recorded from 15 patients and 15 healthy controls and decomposed into MU action potential (MUAP) spike trains. MUAP amplitude, firing rate, and magnitude-squared coherence between spike trains were compared across groups. Results showed that MUAPs had significantly lower amplitudes during contractions on the patients’ left PFM, and delta-band coherence was significantly higher at rest on their right PFM compared to controls. These findings suggest altered PFM tissue and neuromuscular control in women with IC/BPS and pelvic floor myalgia. Our results demonstrate that HD-sEMG can provide novel insights into IC/BPS-related PFM dysfunction and biomarkers that help identify subgroups of IC/BPS patients, which may aid their diagnosis and treatment.https://www.mdpi.com/1424-8220/24/23/7417coherencehigh-density surface electromyographyinterstitial cystitis/bladder pain syndromemotor unitpelvic floor muscles |
| spellingShingle | Monica Albaladejo-Belmonte Michael Houston Nicholas Dias Theresa Spitznagle Henry Lai Yingchun Zhang Javier Garcia-Casado Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study Sensors coherence high-density surface electromyography interstitial cystitis/bladder pain syndrome motor unit pelvic floor muscles |
| title | Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study |
| title_full | Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study |
| title_fullStr | Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study |
| title_full_unstemmed | Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study |
| title_short | Does Muscle Pain Induce Alterations in the Pelvic Floor Motor Unit Activity Properties in Interstitial Cystitis/Bladder Pain Syndrome? A High-Density sEMG-Based Study |
| title_sort | does muscle pain induce alterations in the pelvic floor motor unit activity properties in interstitial cystitis bladder pain syndrome a high density semg based study |
| topic | coherence high-density surface electromyography interstitial cystitis/bladder pain syndrome motor unit pelvic floor muscles |
| url | https://www.mdpi.com/1424-8220/24/23/7417 |
| work_keys_str_mv | AT monicaalbaladejobelmonte doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy AT michaelhouston doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy AT nicholasdias doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy AT theresaspitznagle doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy AT henrylai doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy AT yingchunzhang doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy AT javiergarciacasado doesmusclepaininducealterationsinthepelvicfloormotorunitactivitypropertiesininterstitialcystitisbladderpainsyndromeahighdensitysemgbasedstudy |