Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis
Background. Long regimens for the treatment of post-kala-azar dermal leishmaniasis (PKDL) result in noncompliance. A safe, effective, and acceptable regimen for the treatment of PKDL is still to be developed. Miltefosine has been found to be effective in the treatment of Visceral Leishmaniasis (VL)...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/414378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524445228826624 |
|---|---|
| author | Shyam Sundar Anup Singh Jaya Chakravarty Madhukar Rai |
| author_facet | Shyam Sundar Anup Singh Jaya Chakravarty Madhukar Rai |
| author_sort | Shyam Sundar |
| collection | DOAJ |
| description | Background. Long regimens for the treatment of post-kala-azar dermal leishmaniasis (PKDL) result in noncompliance. A safe, effective, and acceptable regimen for the treatment of PKDL is still to be developed. Miltefosine has been found to be effective in the treatment of Visceral Leishmaniasis (VL). Hence, its efficacy was tested in patients of PKDL. Methods. In this exploratory study, 33 patients with PKDL aged 10 years and above were administered miltefosine (50 mg for those weighing <25 kg or 100 mg in divided doses for those ≥25 kg and 2.5 mg per kg for children) for 12 weeks and followed up for one year to find out the efficacy. Results. Out of 33 patients, 3 patients withdrew consent. Treatment was stopped due to adverse effect in 1 patient. 28 (96.6%) got cured with complete disappearance of lesion while 1 patient (3.4%) failed treatment by protocol analysis. Conclusion. Miltefosine was found to be effective and safe in the treatment of PKDL. |
| format | Article |
| id | doaj-art-388ebec7933d4bca934b88400bd0d11b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-388ebec7933d4bca934b88400bd0d11b2025-02-03T05:53:12ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/414378414378Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal LeishmaniasisShyam Sundar0Anup Singh1Jaya Chakravarty2Madhukar Rai3Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, IndiaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, IndiaDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, IndiaBackground. Long regimens for the treatment of post-kala-azar dermal leishmaniasis (PKDL) result in noncompliance. A safe, effective, and acceptable regimen for the treatment of PKDL is still to be developed. Miltefosine has been found to be effective in the treatment of Visceral Leishmaniasis (VL). Hence, its efficacy was tested in patients of PKDL. Methods. In this exploratory study, 33 patients with PKDL aged 10 years and above were administered miltefosine (50 mg for those weighing <25 kg or 100 mg in divided doses for those ≥25 kg and 2.5 mg per kg for children) for 12 weeks and followed up for one year to find out the efficacy. Results. Out of 33 patients, 3 patients withdrew consent. Treatment was stopped due to adverse effect in 1 patient. 28 (96.6%) got cured with complete disappearance of lesion while 1 patient (3.4%) failed treatment by protocol analysis. Conclusion. Miltefosine was found to be effective and safe in the treatment of PKDL.http://dx.doi.org/10.1155/2015/414378 |
| spellingShingle | Shyam Sundar Anup Singh Jaya Chakravarty Madhukar Rai Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis The Scientific World Journal |
| title | Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis |
| title_full | Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis |
| title_fullStr | Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis |
| title_full_unstemmed | Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis |
| title_short | Efficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis |
| title_sort | efficacy and safety of miltefosine in treatment of post kala azar dermal leishmaniasis |
| url | http://dx.doi.org/10.1155/2015/414378 |
| work_keys_str_mv | AT shyamsundar efficacyandsafetyofmiltefosineintreatmentofpostkalaazardermalleishmaniasis AT anupsingh efficacyandsafetyofmiltefosineintreatmentofpostkalaazardermalleishmaniasis AT jayachakravarty efficacyandsafetyofmiltefosineintreatmentofpostkalaazardermalleishmaniasis AT madhukarrai efficacyandsafetyofmiltefosineintreatmentofpostkalaazardermalleishmaniasis |