Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome
Neuromyelitis optica (NMO), or Devic’s disease, is one of the demyelinating disorders of the central nervous system, with autoimmune inflammatory etiology. The optic nerves and spinal cord are the major organs involved in the disease; however, the involvement of the brain can also be seen in rare in...
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | APIK Journal of Internal Medicine |
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| Online Access: | https://journals.lww.com/10.4103/ajim.ajim_167_22 |
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| author | Darshankumar Manubhai Raval Vaishnavi Mahendrasinh Rathod Tejasvi Patel |
| author_facet | Darshankumar Manubhai Raval Vaishnavi Mahendrasinh Rathod Tejasvi Patel |
| author_sort | Darshankumar Manubhai Raval |
| collection | DOAJ |
| description | Neuromyelitis optica (NMO), or Devic’s disease, is one of the demyelinating disorders of the central nervous system, with autoimmune inflammatory etiology. The optic nerves and spinal cord are the major organs involved in the disease; however, the involvement of the brain can also be seen in rare instances. Here, we report a case of a 34-year-old female, diagnosed with NMO and concurrent nephrotic syndrome (NS). NMO was diagnosed by positive Aquaporin-4 antibodies in the serum, radio imaging such as magnetic resonance imaging of the brain and spinal cord showing the demyelinating lesions, as well as the presence of optic neuritis on visually evoked potential. Biochemical investigations revealed heavy proteinuria, hypoalbuminemia, and hypertriglyceridemia, meeting the diagnostic criteria of NS. Therefore, considering the diagnosis of NMO with NS, the patient was treated with plasmapheresis and methylprednisolone pulse therapy. This concurrence is very uncommon in clinical practice, as previously only two such cases are reported to date. |
| format | Article |
| id | doaj-art-388c2d4645274acca0699eecd7d4bf24 |
| institution | Kabale University |
| issn | 2666-1802 2666-1810 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | APIK Journal of Internal Medicine |
| spelling | doaj-art-388c2d4645274acca0699eecd7d4bf242025-08-20T03:31:40ZengWolters Kluwer Medknow PublicationsAPIK Journal of Internal Medicine2666-18022666-18102025-07-0113322422610.4103/ajim.ajim_167_22Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic SyndromeDarshankumar Manubhai RavalVaishnavi Mahendrasinh RathodTejasvi PatelNeuromyelitis optica (NMO), or Devic’s disease, is one of the demyelinating disorders of the central nervous system, with autoimmune inflammatory etiology. The optic nerves and spinal cord are the major organs involved in the disease; however, the involvement of the brain can also be seen in rare instances. Here, we report a case of a 34-year-old female, diagnosed with NMO and concurrent nephrotic syndrome (NS). NMO was diagnosed by positive Aquaporin-4 antibodies in the serum, radio imaging such as magnetic resonance imaging of the brain and spinal cord showing the demyelinating lesions, as well as the presence of optic neuritis on visually evoked potential. Biochemical investigations revealed heavy proteinuria, hypoalbuminemia, and hypertriglyceridemia, meeting the diagnostic criteria of NS. Therefore, considering the diagnosis of NMO with NS, the patient was treated with plasmapheresis and methylprednisolone pulse therapy. This concurrence is very uncommon in clinical practice, as previously only two such cases are reported to date.https://journals.lww.com/10.4103/ajim.ajim_167_22aquaporin-4 antibodiesdemyelinating diseasedevic’s diseasenephrotic syndromeneuromyelitis opticaneuromyelitis optica spectrum disorder |
| spellingShingle | Darshankumar Manubhai Raval Vaishnavi Mahendrasinh Rathod Tejasvi Patel Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome APIK Journal of Internal Medicine aquaporin-4 antibodies demyelinating disease devic’s disease nephrotic syndrome neuromyelitis optica neuromyelitis optica spectrum disorder |
| title | Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome |
| title_full | Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome |
| title_fullStr | Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome |
| title_full_unstemmed | Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome |
| title_short | Postinfectious Aquaporin-4-positive Neuromyelitis Optica Syndrome Disorder and Nephrotic Syndrome |
| title_sort | postinfectious aquaporin 4 positive neuromyelitis optica syndrome disorder and nephrotic syndrome |
| topic | aquaporin-4 antibodies demyelinating disease devic’s disease nephrotic syndrome neuromyelitis optica neuromyelitis optica spectrum disorder |
| url | https://journals.lww.com/10.4103/ajim.ajim_167_22 |
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