CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy

CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy

IntroductionCDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether CDK2 inhibition specifically facilitate immunogenic cell deat...

Full description

Saved in:
Bibliographic Details
Main Authors: Yu Chen, Wancheng Liu, Qiaomei Cai, Chaohu Pan, Zhenghao Yin, Yijiao Tang, Zhixu He, Genhong Cheng, Liping Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
immunogenic cell death
CDK2
anti-PD-1 therapy
type-1 interferon response
MTX
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570040/full
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items