Inflammatory bowel disease and proteinuria
Inflammatory bowel disease is chronic recurrent inflammatory gastrointestinal tract illness， including Crohn's disease and ulcerative colitis. Few patients develop renal damage and proteinuria. Tumor necrosis factor alpha from intestinal mucosa induces microvascular endothelial dysfunction by c...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2022-12-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.012 |
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| _version_ | 1850143330712682496 |
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| author | Yang Zhi-hui Xu Xiao-chang Dong Ye-jing Zhang Yi-min |
| author_facet | Yang Zhi-hui Xu Xiao-chang Dong Ye-jing Zhang Yi-min |
| author_sort | Yang Zhi-hui |
| collection | DOAJ |
| description | Inflammatory bowel disease is chronic recurrent inflammatory gastrointestinal tract illness， including Crohn's disease and ulcerative colitis. Few patients develop renal damage and proteinuria. Tumor necrosis factor alpha from intestinal mucosa induces microvascular endothelial dysfunction by changing the structure and function of endothelium. Also it played a key role in the formation of proteinuria. This review attempted to explore the relationship between inflammatory bowel disease and proteinuria from the perspectives of intestinal mucosal immune disorder and gut-renal connection at the levels of gene， microorganism and diet. Proteinuria may become a simple and non-invasive marker of inflammatory bowel disease activity. Finally the latest developments of targeted therapeutic agents based upon intestinal mucosal immunity and fecal bacteria transplantation were summarized for managing proteinuria. |
| format | Article |
| id | doaj-art-3884ffafeb184e2faf4167ed3f1b21a5 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-12-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-3884ffafeb184e2faf4167ed3f1b21a52025-08-20T02:28:45ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-12-01221041104633236709Inflammatory bowel disease and proteinuriaYang Zhi-huiXu Xiao-changDong Ye-jingZhang Yi-minInflammatory bowel disease is chronic recurrent inflammatory gastrointestinal tract illness， including Crohn's disease and ulcerative colitis. Few patients develop renal damage and proteinuria. Tumor necrosis factor alpha from intestinal mucosa induces microvascular endothelial dysfunction by changing the structure and function of endothelium. Also it played a key role in the formation of proteinuria. This review attempted to explore the relationship between inflammatory bowel disease and proteinuria from the perspectives of intestinal mucosal immune disorder and gut-renal connection at the levels of gene， microorganism and diet. Proteinuria may become a simple and non-invasive marker of inflammatory bowel disease activity. Finally the latest developments of targeted therapeutic agents based upon intestinal mucosal immunity and fecal bacteria transplantation were summarized for managing proteinuria.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.012Inflammatory bowel diseaseProteinuriaTumor necrosis factor-αTargeted therapy |
| spellingShingle | Yang Zhi-hui Xu Xiao-chang Dong Ye-jing Zhang Yi-min Inflammatory bowel disease and proteinuria Linchuang shenzangbing zazhi Inflammatory bowel disease Proteinuria Tumor necrosis factor-α Targeted therapy |
| title | Inflammatory bowel disease and proteinuria |
| title_full | Inflammatory bowel disease and proteinuria |
| title_fullStr | Inflammatory bowel disease and proteinuria |
| title_full_unstemmed | Inflammatory bowel disease and proteinuria |
| title_short | Inflammatory bowel disease and proteinuria |
| title_sort | inflammatory bowel disease and proteinuria |
| topic | Inflammatory bowel disease Proteinuria Tumor necrosis factor-α Targeted therapy |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.012 |
| work_keys_str_mv | AT yangzhihui inflammatoryboweldiseaseandproteinuria AT xuxiaochang inflammatoryboweldiseaseandproteinuria AT dongyejing inflammatoryboweldiseaseandproteinuria AT zhangyimin inflammatoryboweldiseaseandproteinuria |