Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease
Abstract. Platelets play an important role in thrombosis caused by acute coronary syndrome and stroke. As the main platelet collagen receptor, platelet glycoprotein Ⅵ (GPⅥ) is an important modulator in the activation and aggregation of platelets at vascular injury sites. Recently, GPⅥ has been ident...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2024-12-01
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| Series: | Cardiology Discovery |
| Online Access: | http://journals.lww.com/10.1097/CD9.0000000000000137 |
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| _version_ | 1849701536862568448 |
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| author | Menglu Liu Xueyan Zhao Hanjia Gao |
| author_facet | Menglu Liu Xueyan Zhao Hanjia Gao |
| author_sort | Menglu Liu |
| collection | DOAJ |
| description | Abstract. Platelets play an important role in thrombosis caused by acute coronary syndrome and stroke. As the main platelet collagen receptor, platelet glycoprotein Ⅵ (GPⅥ) is an important modulator in the activation and aggregation of platelets at vascular injury sites. Recently, GPⅥ has been identified as a potent antithrombotic target. The structure, properties, functions, and downstream signaling of GPⅥ are reviewed; its relationship with bleeding, thrombosis, and other diseases are discussed; and potential of GPⅥ as a future antiplatelet therapeutic target is summarized in this article. |
| format | Article |
| id | doaj-art-3882401fdb084cd79d4fca29ac11f811 |
| institution | DOAJ |
| issn | 2096-952X 2693-8499 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Discovery |
| spelling | doaj-art-3882401fdb084cd79d4fca29ac11f8112025-08-20T03:17:55ZengWolters Kluwer Health/LWWCardiology Discovery2096-952X2693-84992024-12-014430931810.1097/CD9.0000000000000137202412000-00007Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular DiseaseMenglu Liu0Xueyan Zhao1Hanjia GaoDepartment of Cardiology, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Cardiology, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaAbstract. Platelets play an important role in thrombosis caused by acute coronary syndrome and stroke. As the main platelet collagen receptor, platelet glycoprotein Ⅵ (GPⅥ) is an important modulator in the activation and aggregation of platelets at vascular injury sites. Recently, GPⅥ has been identified as a potent antithrombotic target. The structure, properties, functions, and downstream signaling of GPⅥ are reviewed; its relationship with bleeding, thrombosis, and other diseases are discussed; and potential of GPⅥ as a future antiplatelet therapeutic target is summarized in this article.http://journals.lww.com/10.1097/CD9.0000000000000137 |
| spellingShingle | Menglu Liu Xueyan Zhao Hanjia Gao Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease Cardiology Discovery |
| title | Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease |
| title_full | Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease |
| title_fullStr | Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease |
| title_full_unstemmed | Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease |
| title_short | Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease |
| title_sort | platelet glycoprotein vi a novel target for antithrombotic therapy in cardiovascular disease |
| url | http://journals.lww.com/10.1097/CD9.0000000000000137 |
| work_keys_str_mv | AT mengluliu plateletglycoproteinvianoveltargetforantithrombotictherapyincardiovasculardisease AT xueyanzhao plateletglycoproteinvianoveltargetforantithrombotictherapyincardiovasculardisease AT hanjiagao plateletglycoproteinvianoveltargetforantithrombotictherapyincardiovasculardisease |