Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives
Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA). Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The rel...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/302802 |
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| author | Sheara Williamson Deepti Varma Michael Brown Susan Jansen |
| author_facet | Sheara Williamson Deepti Varma Michael Brown Susan Jansen |
| author_sort | Sheara Williamson |
| collection | DOAJ |
| description | Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA). Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown. Purpose. To determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged AA hypertensives. Methods. Ten sedentary hypertensive AA underwent 50 min of aerobic exercise at 65% VO2max. Urine was collected for 24 hr on two occasions, prior to testing and immediately following the bout of exercise. Urinary metabolites of prostacyclin (6-keto PGF1α) and thromboxane (11-dTXB2) were measured during the day and night periods by high-performance liquid chromatography (HPLC). Results. 6-keto PGF1α levels significantly increased (𝑃=.04) following the bout of exercise compared to the control day. There was a significant relationship (𝑟=.49, 𝑃<.05) between 6-keto PGF1α levels and VO2max during the exercise day. Conclusion. Based on this preliminary study, there appears to be a relationship between aerobic capacity and exercise-induced 6-keto PGF1α production in middle-aged hypertensive AAs. AAs with lower VO2max had lower 6-keto PGF1α formation. |
| format | Article |
| id | doaj-art-387ace4582eb4a46a309f71b92d90aba |
| institution | OA Journals |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-387ace4582eb4a46a309f71b92d90aba2025-08-20T02:38:57ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/302802302802Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 HypertensivesSheara Williamson0Deepti Varma1Michael Brown2Susan Jansen3Hypertension, Molecular, and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 North Broad Street, Philadelphia, PA 19122, USADepartment of Chemistry, Temple University, Philadelphia, PA 19122, USAHypertension, Molecular, and Applied Physiology Laboratory, Department of Kinesiology, Temple University, 1800 North Broad Street, Philadelphia, PA 19122, USADepartment of Chemistry, Temple University, Philadelphia, PA 19122, USAEndothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA). Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown. Purpose. To determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged AA hypertensives. Methods. Ten sedentary hypertensive AA underwent 50 min of aerobic exercise at 65% VO2max. Urine was collected for 24 hr on two occasions, prior to testing and immediately following the bout of exercise. Urinary metabolites of prostacyclin (6-keto PGF1α) and thromboxane (11-dTXB2) were measured during the day and night periods by high-performance liquid chromatography (HPLC). Results. 6-keto PGF1α levels significantly increased (𝑃=.04) following the bout of exercise compared to the control day. There was a significant relationship (𝑟=.49, 𝑃<.05) between 6-keto PGF1α levels and VO2max during the exercise day. Conclusion. Based on this preliminary study, there appears to be a relationship between aerobic capacity and exercise-induced 6-keto PGF1α production in middle-aged hypertensive AAs. AAs with lower VO2max had lower 6-keto PGF1α formation.http://dx.doi.org/10.4061/2011/302802 |
| spellingShingle | Sheara Williamson Deepti Varma Michael Brown Susan Jansen Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives Journal of Aging Research |
| title | Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives |
| title_full | Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives |
| title_fullStr | Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives |
| title_full_unstemmed | Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives |
| title_short | Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives |
| title_sort | eicosanoid production following one bout of exercise in middle aged african american pre and stage 1 hypertensives |
| url | http://dx.doi.org/10.4061/2011/302802 |
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