The unexpected role of the STING protein in lipid metabolism
Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the activation of inflammatory responses in the presence of cytosol...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2023-04-01
|
| Series: | Comptes Rendus Biologies |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.110/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206347505860608 |
|---|---|
| author | Vila, Isabelle K. Laguette, Nadine |
| author_facet | Vila, Isabelle K. Laguette, Nadine |
| author_sort | Vila, Isabelle K. |
| collection | DOAJ |
| description | Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the activation of inflammatory responses in the presence of cytosolic DNAs. This has prompted a plethora of approaches aiming at modulating STING activation in order to boost or inhibit inflammatory responses. However, recent work has revealed that STING is also a direct regulator of metabolic homeostasis. In particular, STING regulates lipid metabolism directly, a function that is conserved throughout evolution. This indicates that STING targeting strategies must take into consideration potential metabolic side effects that may alter disease course, but also suggests that targeting STING may open the route to novel treatments for metabolic disorders. Here we discuss recent work describing the metabolic function of STING and the implications of these findings. |
| format | Article |
| id | doaj-art-3879728821814a27a8959c346380d2aa |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-3879728821814a27a8959c346380d2aa2025-02-07T10:36:22ZengAcadémie des sciencesComptes Rendus Biologies1768-32382023-04-01346G1293310.5802/crbiol.11010.5802/crbiol.110The unexpected role of the STING protein in lipid metabolismVila, Isabelle K.0https://orcid.org/0000-0002-6834-5721Laguette, Nadine1https://orcid.org/0000-0001-8072-5607IGMM, Université de Montpellier, CNRS, Montpellier, FranceIGMM, Université de Montpellier, CNRS, Montpellier, FranceDetection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the activation of inflammatory responses in the presence of cytosolic DNAs. This has prompted a plethora of approaches aiming at modulating STING activation in order to boost or inhibit inflammatory responses. However, recent work has revealed that STING is also a direct regulator of metabolic homeostasis. In particular, STING regulates lipid metabolism directly, a function that is conserved throughout evolution. This indicates that STING targeting strategies must take into consideration potential metabolic side effects that may alter disease course, but also suggests that targeting STING may open the route to novel treatments for metabolic disorders. Here we discuss recent work describing the metabolic function of STING and the implications of these findings.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.110/STINGMetabolismInnate immunityCytosolic DNAFatty acidsInflammation |
| spellingShingle | Vila, Isabelle K. Laguette, Nadine The unexpected role of the STING protein in lipid metabolism Comptes Rendus Biologies STING Metabolism Innate immunity Cytosolic DNA Fatty acids Inflammation |
| title | The unexpected role of the STING protein in lipid metabolism |
| title_full | The unexpected role of the STING protein in lipid metabolism |
| title_fullStr | The unexpected role of the STING protein in lipid metabolism |
| title_full_unstemmed | The unexpected role of the STING protein in lipid metabolism |
| title_short | The unexpected role of the STING protein in lipid metabolism |
| title_sort | unexpected role of the sting protein in lipid metabolism |
| topic | STING Metabolism Innate immunity Cytosolic DNA Fatty acids Inflammation |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.110/ |
| work_keys_str_mv | AT vilaisabellek theunexpectedroleofthestingproteininlipidmetabolism AT laguettenadine theunexpectedroleofthestingproteininlipidmetabolism AT vilaisabellek unexpectedroleofthestingproteininlipidmetabolism AT laguettenadine unexpectedroleofthestingproteininlipidmetabolism |