How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak
Abstract The September 2024 outbreak of Marburg virus disease (MVD) represented the first time this virus was identified in Rwanda. Health authorities mounted a rapid and effective response, including the rapid execution of an open-label Phase 2 clinical trial of an investigational Marburg vaccine,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01224-8 |
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| author | Sabin Nsanzimana Noella Bigirimana Richard Hatchett Sue Bailey Natacha Butera Yvan Butera Jakob P. Cramer Amy Finan Caroline M. Forkin Adam M. Hacker Sibomana Hassan Vicky Leamy Vincent Mutabazi Julien Nyombayire Eric Remera Edson Rwagasore Eduardo Tedeschi Kelly L. Warfield Nicole Lurie |
| author_facet | Sabin Nsanzimana Noella Bigirimana Richard Hatchett Sue Bailey Natacha Butera Yvan Butera Jakob P. Cramer Amy Finan Caroline M. Forkin Adam M. Hacker Sibomana Hassan Vicky Leamy Vincent Mutabazi Julien Nyombayire Eric Remera Edson Rwagasore Eduardo Tedeschi Kelly L. Warfield Nicole Lurie |
| author_sort | Sabin Nsanzimana |
| collection | DOAJ |
| description | Abstract The September 2024 outbreak of Marburg virus disease (MVD) represented the first time this virus was identified in Rwanda. Health authorities mounted a rapid and effective response, including the rapid execution of an open-label Phase 2 clinical trial of an investigational Marburg vaccine, beginning just 10 days after the outbreak was declared. We share lessons from this rapidly executed clinical trial to help encourage outbreak research preparedness in other countries. |
| format | Article |
| id | doaj-art-3878edd44ecb44d69bdb33f6a3fc5c38 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-3878edd44ecb44d69bdb33f6a3fc5c382025-08-20T04:01:46ZengNature Portfolionpj Vaccines2059-01052025-08-011011410.1038/s41541-025-01224-8How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreakSabin Nsanzimana0Noella BigirimanaRichard Hatchett1Sue BaileyNatacha Butera2Yvan Butera3Jakob P. Cramer4Amy Finan5Caroline M. Forkin6Adam M. Hacker7Sibomana Hassan8Vicky Leamy9Vincent Mutabazi10Julien Nyombayire11Eric Remera12Edson Rwagasore13Eduardo Tedeschi14Kelly L. Warfield15Nicole Lurie16Ministry of Health, Government of RwandaCEPIGovernment of RwandaGovernment of RwandaCEPISabin Vaccine InstituteCEPICEPIRwanda Biomedical Center Kigali RwandaIQVIAGovernment of RwandaCenter for Family Health ResearchRwanda Biomedical Center Kigali RwandaRwanda Biomedical Center Kigali RwandaIQVIASabin Vaccine InstituteCEPIAbstract The September 2024 outbreak of Marburg virus disease (MVD) represented the first time this virus was identified in Rwanda. Health authorities mounted a rapid and effective response, including the rapid execution of an open-label Phase 2 clinical trial of an investigational Marburg vaccine, beginning just 10 days after the outbreak was declared. We share lessons from this rapidly executed clinical trial to help encourage outbreak research preparedness in other countries.https://doi.org/10.1038/s41541-025-01224-8 |
| spellingShingle | Sabin Nsanzimana Noella Bigirimana Richard Hatchett Sue Bailey Natacha Butera Yvan Butera Jakob P. Cramer Amy Finan Caroline M. Forkin Adam M. Hacker Sibomana Hassan Vicky Leamy Vincent Mutabazi Julien Nyombayire Eric Remera Edson Rwagasore Eduardo Tedeschi Kelly L. Warfield Nicole Lurie How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak npj Vaccines |
| title | How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak |
| title_full | How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak |
| title_fullStr | How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak |
| title_full_unstemmed | How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak |
| title_short | How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak |
| title_sort | how rwanda mounted a research response with an investigational vaccine just ten days into a marburg outbreak |
| url | https://doi.org/10.1038/s41541-025-01224-8 |
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