Genetics of Cerebral Vasospasm
Cerebral vasospasm (CV) is a major source of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH). It is thought that an inflammatory cascade initiated by extravasated blood products precipitates CV, disrupting vascular smooth muscle cell function of major cerebral arteries, leading...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/291895 |
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| author | Travis R. Ladner Scott L. Zuckerman J Mocco |
| author_facet | Travis R. Ladner Scott L. Zuckerman J Mocco |
| author_sort | Travis R. Ladner |
| collection | DOAJ |
| description | Cerebral vasospasm (CV) is a major source of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH). It is thought that an inflammatory cascade initiated by extravasated blood products precipitates CV, disrupting vascular smooth muscle cell function of major cerebral arteries, leading to vasoconstriction. Mechanisms of CV and modes of therapy are an active area of research. Understanding the genetic basis of CV holds promise for the recognition and treatment for this devastating neurovascular event. In our review, we summarize the most recent research involving key areas within the genetics and vasospasm discussion: (1) Prognostic role of genetics—risk stratification based on gene sequencing, biomarkers, and polymorphisms; (2) Signaling pathways—pinpointing key inflammatory molecules responsible for downstream cellular signaling and altering these mediators to provide therapeutic benefit; and (3) Gene therapy and gene delivery—using viral vectors or novel protein delivery methods to overexpress protective genes in the vasospasm cascade. |
| format | Article |
| id | doaj-art-387854bde06c440599e5668711f4e686 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-387854bde06c440599e5668711f4e6862025-02-03T01:10:05ZengWileyNeurology Research International2090-18522090-18602013-01-01201310.1155/2013/291895291895Genetics of Cerebral VasospasmTravis R. Ladner0Scott L. Zuckerman1J Mocco2Vanderbilt University School of Medicine, Nashville, TN 37212, USADepartment of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USADepartment of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USACerebral vasospasm (CV) is a major source of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH). It is thought that an inflammatory cascade initiated by extravasated blood products precipitates CV, disrupting vascular smooth muscle cell function of major cerebral arteries, leading to vasoconstriction. Mechanisms of CV and modes of therapy are an active area of research. Understanding the genetic basis of CV holds promise for the recognition and treatment for this devastating neurovascular event. In our review, we summarize the most recent research involving key areas within the genetics and vasospasm discussion: (1) Prognostic role of genetics—risk stratification based on gene sequencing, biomarkers, and polymorphisms; (2) Signaling pathways—pinpointing key inflammatory molecules responsible for downstream cellular signaling and altering these mediators to provide therapeutic benefit; and (3) Gene therapy and gene delivery—using viral vectors or novel protein delivery methods to overexpress protective genes in the vasospasm cascade.http://dx.doi.org/10.1155/2013/291895 |
| spellingShingle | Travis R. Ladner Scott L. Zuckerman J Mocco Genetics of Cerebral Vasospasm Neurology Research International |
| title | Genetics of Cerebral Vasospasm |
| title_full | Genetics of Cerebral Vasospasm |
| title_fullStr | Genetics of Cerebral Vasospasm |
| title_full_unstemmed | Genetics of Cerebral Vasospasm |
| title_short | Genetics of Cerebral Vasospasm |
| title_sort | genetics of cerebral vasospasm |
| url | http://dx.doi.org/10.1155/2013/291895 |
| work_keys_str_mv | AT travisrladner geneticsofcerebralvasospasm AT scottlzuckerman geneticsofcerebralvasospasm AT jmocco geneticsofcerebralvasospasm |