Temporal and spatial characterization of keratinocytes supporting orf virus replication

Temporal and spatial characterization of keratinocytes supporting orf virus replication

Reflecting their tropism for keratinocytes, most poxviruses that infect vertebrates replicate to high titers and cause pathology in the skin. Keratinocytes, the main cells of the epidermis, are found in different stages of a differentiation program that produces the critical barrier against environm...

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Bibliographic Details
Main Authors: Byung-Joon Seung, Sushil Khatiwada, Daniel L. Rock, Gustavo Delhon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
orf virus
pathogenesis
keratinocytes
full thickness wound skin model
sheep
in situ hybridization (ISH)
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1486778/full
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