Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND)
Background A high minute ventilation/rate of carbon dioxide production (V̇E/V̇co2) slope during exercise is prognostic for cardiovascular death. Recent data indicate that adults with either controlled or untreated primary hypertension, but not those with uncontrolled hypertension, exhibit a higher V...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-08-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.034114 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849725384241709056 |
|---|---|
| author | Joseph C. Watso Austin T. Robinson Ross Arena Matthew P. Harber Leonard A. Kaminsky Jonathan Myers |
| author_facet | Joseph C. Watso Austin T. Robinson Ross Arena Matthew P. Harber Leonard A. Kaminsky Jonathan Myers |
| author_sort | Joseph C. Watso |
| collection | DOAJ |
| description | Background A high minute ventilation/rate of carbon dioxide production (V̇E/V̇co2) slope during exercise is prognostic for cardiovascular death. Recent data indicate that adults with either controlled or untreated primary hypertension, but not those with uncontrolled hypertension, exhibit a higher V̇E/V̇co2 slope during exercise. However, the sample sizes were modest. Therefore, we used the Fitness Registry and the Importance of Exercise National Database to determine whether adults with hypertension, particularly those with controlled or untreated hypertension, exhibit higher V̇E/V̇co2 slopes compared with adults without hypertension. Methods and Results Using the Fitness Registry and the Importance of Exercise National Database, we isolated primary hypertension by excluding those with any disease other than hypertension or taking any medications other than antihypertension medications. We also excluded current smokers and those with obesity. The V̇E/V̇co2 slope was determined during a peak cycling exercise test. All data are presented as median [interquartile range]. We compared groups using linear regression adjusted for age, male/female, and body mass index. The characteristics of the entire sample (n=4109) were age, 42 [18] years; 48% women; body mass index, 26 [4] kg/m2. The V̇E/V̇co2 slope did not differ between adults with hypertension (n=1940; 24.7 [3.7]) compared with those without hypertension (n=2169; 24.9 [3.8]) (hypertension versus no hypertension, P=0.31; overall model: R2=0.07, F4,4104=73.0; P<0.001). Further, the V̇E/V̇co2 slope did not differ between adults with medication‐controlled hypertension (n=107; 24.4 [3.0]), untreated hypertension (n=1626; 24.8 [3.9]), uncontrolled hypertension (n=207; 24.8 [3.0]), or those without hypertension (n=2169; 24.9 [3.8]) (hypertension subgroup versus no hypertension, P≥0.06; overall model: R2=0.07, F6,4102=49.6, P<0.001). Conclusions Primary hypertension is not associated with V̇E/V̇co2 slope in the Fitness Registry and the Importance of Exercise National Database. |
| format | Article |
| id | doaj-art-386e022e7a9141b7886192e0f7efbc4d |
| institution | DOAJ |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-386e022e7a9141b7886192e0f7efbc4d2025-08-20T03:10:28ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-08-01131510.1161/JAHA.123.034114Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND)Joseph C. Watso0Austin T. Robinson1Ross Arena2Matthew P. Harber3Leonard A. Kaminsky4Jonathan Myers5Cardiovascular and Applied Physiology Laboratory Florida State University Tallahassee FLNeurovascular Physiology Laboratory Indiana University Bloomington INHealthy Living for Pandemic Event Protection (HL‐PIVOT) Network Chicago ILHealthy Living for Pandemic Event Protection (HL‐PIVOT) Network Chicago ILHealthy Living for Pandemic Event Protection (HL‐PIVOT) Network Chicago ILHealthy Living for Pandemic Event Protection (HL‐PIVOT) Network Chicago ILBackground A high minute ventilation/rate of carbon dioxide production (V̇E/V̇co2) slope during exercise is prognostic for cardiovascular death. Recent data indicate that adults with either controlled or untreated primary hypertension, but not those with uncontrolled hypertension, exhibit a higher V̇E/V̇co2 slope during exercise. However, the sample sizes were modest. Therefore, we used the Fitness Registry and the Importance of Exercise National Database to determine whether adults with hypertension, particularly those with controlled or untreated hypertension, exhibit higher V̇E/V̇co2 slopes compared with adults without hypertension. Methods and Results Using the Fitness Registry and the Importance of Exercise National Database, we isolated primary hypertension by excluding those with any disease other than hypertension or taking any medications other than antihypertension medications. We also excluded current smokers and those with obesity. The V̇E/V̇co2 slope was determined during a peak cycling exercise test. All data are presented as median [interquartile range]. We compared groups using linear regression adjusted for age, male/female, and body mass index. The characteristics of the entire sample (n=4109) were age, 42 [18] years; 48% women; body mass index, 26 [4] kg/m2. The V̇E/V̇co2 slope did not differ between adults with hypertension (n=1940; 24.7 [3.7]) compared with those without hypertension (n=2169; 24.9 [3.8]) (hypertension versus no hypertension, P=0.31; overall model: R2=0.07, F4,4104=73.0; P<0.001). Further, the V̇E/V̇co2 slope did not differ between adults with medication‐controlled hypertension (n=107; 24.4 [3.0]), untreated hypertension (n=1626; 24.8 [3.9]), uncontrolled hypertension (n=207; 24.8 [3.0]), or those without hypertension (n=2169; 24.9 [3.8]) (hypertension subgroup versus no hypertension, P≥0.06; overall model: R2=0.07, F6,4102=49.6, P<0.001). Conclusions Primary hypertension is not associated with V̇E/V̇co2 slope in the Fitness Registry and the Importance of Exercise National Database.https://www.ahajournals.org/doi/10.1161/JAHA.123.034114cardiopulmonary exercise testingcardiorespiratory fitnesscardiovascular diseaserespiratory |
| spellingShingle | Joseph C. Watso Austin T. Robinson Ross Arena Matthew P. Harber Leonard A. Kaminsky Jonathan Myers Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND) Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiopulmonary exercise testing cardiorespiratory fitness cardiovascular disease respiratory |
| title | Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND) |
| title_full | Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND) |
| title_fullStr | Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND) |
| title_full_unstemmed | Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND) |
| title_short | Hypertension and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND) |
| title_sort | hypertension and ventilatory responses during exercise in the fitness registry and the importance of exercise national database friend |
| topic | cardiopulmonary exercise testing cardiorespiratory fitness cardiovascular disease respiratory |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.034114 |
| work_keys_str_mv | AT josephcwatso hypertensionandventilatoryresponsesduringexerciseinthefitnessregistryandtheimportanceofexercisenationaldatabasefriend AT austintrobinson hypertensionandventilatoryresponsesduringexerciseinthefitnessregistryandtheimportanceofexercisenationaldatabasefriend AT rossarena hypertensionandventilatoryresponsesduringexerciseinthefitnessregistryandtheimportanceofexercisenationaldatabasefriend AT matthewpharber hypertensionandventilatoryresponsesduringexerciseinthefitnessregistryandtheimportanceofexercisenationaldatabasefriend AT leonardakaminsky hypertensionandventilatoryresponsesduringexerciseinthefitnessregistryandtheimportanceofexercisenationaldatabasefriend AT jonathanmyers hypertensionandventilatoryresponsesduringexerciseinthefitnessregistryandtheimportanceofexercisenationaldatabasefriend |