Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure

Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure

Background and objectiveEmerging evidence indicates that inflammation regulates cardiac remodeling and heart failure (HF). IL12β is a subunit for proinflammatory cytokines IL12 and IL23. However, the effect of IL12β inhibition on HF development and the underlying mechanism is not understood.MethodsW...

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Bibliographic Details
Main Authors: Umesh Bhattarai, Xiaochen He, Ziru Niu, Lihong Pan, Dongzhi Wang, Hao Wang, Heng Zeng, Jian-Xiong Chen, Joshua S. Speed, John S. Clemmer, Yingjie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
IL12β
inflammation
heart failure
T cells
macrophages
lung remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1624940/full
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