Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method
Ceftriaxone sodium, an antimicrobial agent that plays an important role in clinical practice, is successfully used to treat infections caused by most Gram-positive and Gram-negative organisms. Since there are few rapid analytical methods for ceftriaxone analysis to use in the pharmaceutical routine,...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/7530242 |
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| author | Patrícia Vidal de Aléssio Ana Carolina Kogawa Hérida Regina Nunes Salgado |
| author_facet | Patrícia Vidal de Aléssio Ana Carolina Kogawa Hérida Regina Nunes Salgado |
| author_sort | Patrícia Vidal de Aléssio |
| collection | DOAJ |
| description | Ceftriaxone sodium, an antimicrobial agent that plays an important role in clinical practice, is successfully used to treat infections caused by most Gram-positive and Gram-negative organisms. Since there are few rapid analytical methods for ceftriaxone analysis to use in the pharmaceutical routine, the aim of this research was to develop a new method able to quantify this cephalosporin. Therefore, a sensitive, rapid, simple UV spectrophotometric method for the determination and quantification of ceftriaxone sodium was proposed. The UV detector was set at 241 nm. Beer’s law obeyed the concentration range of 10–20 µg mL−1. Statistical comparison of the results with a well-established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision. Intra- and interday variability for the method were less than 2% relative standard deviation. The proposed method was applied to the determination of the examined drugs in pharmaceutical formulations and the results demonstrated that the method is equally accurate, precise, and reproducible as the official methods. |
| format | Article |
| id | doaj-art-3867d53addbe4e32b59094c4e8c5acef |
| institution | OA Journals |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-3867d53addbe4e32b59094c4e8c5acef2025-08-20T02:38:58ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732017-01-01201710.1155/2017/75302427530242Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric MethodPatrícia Vidal de Aléssio0Ana Carolina Kogawa1Hérida Regina Nunes Salgado2Department of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista (UNESP), Araraquara, SP, BrazilDepartment of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista (UNESP), Araraquara, SP, BrazilDepartment of Pharmaceutics, School of Pharmaceutical Sciences of Araraquara, Universidade Estadual Paulista (UNESP), Araraquara, SP, BrazilCeftriaxone sodium, an antimicrobial agent that plays an important role in clinical practice, is successfully used to treat infections caused by most Gram-positive and Gram-negative organisms. Since there are few rapid analytical methods for ceftriaxone analysis to use in the pharmaceutical routine, the aim of this research was to develop a new method able to quantify this cephalosporin. Therefore, a sensitive, rapid, simple UV spectrophotometric method for the determination and quantification of ceftriaxone sodium was proposed. The UV detector was set at 241 nm. Beer’s law obeyed the concentration range of 10–20 µg mL−1. Statistical comparison of the results with a well-established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision. Intra- and interday variability for the method were less than 2% relative standard deviation. The proposed method was applied to the determination of the examined drugs in pharmaceutical formulations and the results demonstrated that the method is equally accurate, precise, and reproducible as the official methods.http://dx.doi.org/10.1155/2017/7530242 |
| spellingShingle | Patrícia Vidal de Aléssio Ana Carolina Kogawa Hérida Regina Nunes Salgado Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method Journal of Analytical Methods in Chemistry |
| title | Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method |
| title_full | Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method |
| title_fullStr | Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method |
| title_full_unstemmed | Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method |
| title_short | Quality of Ceftriaxone Sodium in Lyophilized Powder for Injection Evaluated by Clean, Fast, and Efficient Spectrophotometric Method |
| title_sort | quality of ceftriaxone sodium in lyophilized powder for injection evaluated by clean fast and efficient spectrophotometric method |
| url | http://dx.doi.org/10.1155/2017/7530242 |
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