Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity
In this study, an improved method combining natural surfactants with a solvent–antisolvent precipitation technique was developed to prepare highly effective nano-sized tangeretin particles. Various natural surfactants were tested and compared, and the formulation was optimized using Plackett–Burman...
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MDPI AG
2025-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/15/11/791 |
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| author | Yan Huang Wenxuan Huang Xiaonan Zhang Zhiwei Liu |
| author_facet | Yan Huang Wenxuan Huang Xiaonan Zhang Zhiwei Liu |
| author_sort | Yan Huang |
| collection | DOAJ |
| description | In this study, an improved method combining natural surfactants with a solvent–antisolvent precipitation technique was developed to prepare highly effective nano-sized tangeretin particles. Various natural surfactants were tested and compared, and the formulation was optimized using Plackett–Burman and Box–Behnken design methodologies. The optimal preparation conditions were identified as follows: a tangeretin–dimethyl sulfoxide (DMSO) solution concentration of 5.23 mg/mL, surfactant concentration of 4.72%, and a rotor diameter of 20 mm. Under these conditions, uniform nano-tangeretin particles with an average size of 428.73 ± 30.25 nm were successfully produced. The preparation process significantly reduced particle size without chemical structure of tangeretin, as confirmed by spectral analysis. Importantly, the free radical scavenging activity of the nano-tangeretin was markedly enhanced, showing 65.4% increase in DPPH radical inhibition compared to the unprocessed powder. These results demonstrate that the proposed method can improve the bioactivity and dispersibility of tangeretin, providing a valuable strategy for the efficient utilization and industrial-scale production of bioactive compounds from natural resources. |
| format | Article |
| id | doaj-art-3864af9dc18146eeaff554c060c6cf1b |
| institution | DOAJ |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Nanomaterials |
| spelling | doaj-art-3864af9dc18146eeaff554c060c6cf1b2025-08-20T03:11:22ZengMDPI AGNanomaterials2079-49912025-05-01151179110.3390/nano15110791Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant ActivityYan Huang0Wenxuan Huang1Xiaonan Zhang2Zhiwei Liu3Life Science College, Jiaying University, Meizhou 514000, ChinaLife Science College, Jiaying University, Meizhou 514000, ChinaLife Science College, Jiaying University, Meizhou 514000, ChinaLife Science College, Jiaying University, Meizhou 514000, ChinaIn this study, an improved method combining natural surfactants with a solvent–antisolvent precipitation technique was developed to prepare highly effective nano-sized tangeretin particles. Various natural surfactants were tested and compared, and the formulation was optimized using Plackett–Burman and Box–Behnken design methodologies. The optimal preparation conditions were identified as follows: a tangeretin–dimethyl sulfoxide (DMSO) solution concentration of 5.23 mg/mL, surfactant concentration of 4.72%, and a rotor diameter of 20 mm. Under these conditions, uniform nano-tangeretin particles with an average size of 428.73 ± 30.25 nm were successfully produced. The preparation process significantly reduced particle size without chemical structure of tangeretin, as confirmed by spectral analysis. Importantly, the free radical scavenging activity of the nano-tangeretin was markedly enhanced, showing 65.4% increase in DPPH radical inhibition compared to the unprocessed powder. These results demonstrate that the proposed method can improve the bioactivity and dispersibility of tangeretin, providing a valuable strategy for the efficient utilization and industrial-scale production of bioactive compounds from natural resources.https://www.mdpi.com/2079-4991/15/11/791natural surfactantsnano-tangeretin in particlessolvent–antisolvent precipitationantioxidant activity |
| spellingShingle | Yan Huang Wenxuan Huang Xiaonan Zhang Zhiwei Liu Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity Nanomaterials natural surfactants nano-tangeretin in particles solvent–antisolvent precipitation antioxidant activity |
| title | Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity |
| title_full | Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity |
| title_fullStr | Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity |
| title_full_unstemmed | Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity |
| title_short | Optimization of Nano-Tangeretin Recrystallization via Natural Surfactants in the Antisolvent Precipitation Process: Physicochemical Characterization and Antioxidant Activity |
| title_sort | optimization of nano tangeretin recrystallization via natural surfactants in the antisolvent precipitation process physicochemical characterization and antioxidant activity |
| topic | natural surfactants nano-tangeretin in particles solvent–antisolvent precipitation antioxidant activity |
| url | https://www.mdpi.com/2079-4991/15/11/791 |
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