A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease
A variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual aggregometry technique is the reference method, even having high inter-laboratory variability. The automated coagulation analyzers offer sev...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-08-01
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| Series: | Journal of Laboratory Medicine |
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| Online Access: | https://doi.org/10.1515/labmed-2024-0160 |
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| author | Boulassel Mohamed-Rachid Abdellatif Hussein Al-Falahi Karima Al-Hashmi Fatma Bouchareb Yassine Al-Abri Buthaina Al-Jahdhami Habib |
| author_facet | Boulassel Mohamed-Rachid Abdellatif Hussein Al-Falahi Karima Al-Hashmi Fatma Bouchareb Yassine Al-Abri Buthaina Al-Jahdhami Habib |
| author_sort | Boulassel Mohamed-Rachid |
| collection | DOAJ |
| description | A variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual aggregometry technique is the reference method, even having high inter-laboratory variability. The automated coagulation analyzers offer several advantages for routine testing. Herein the performance of the automated Sysmex CS2000/2100i analyzer was compared to the manual aggregometer Chrono-log 700 for assessing VWF:Co activity in patients suspected of having von Willebrand disease (VWD). |
| format | Article |
| id | doaj-art-3851cf6a7b0e4dccb2e5d59bfbcb6555 |
| institution | DOAJ |
| issn | 2567-9430 2567-9449 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Journal of Laboratory Medicine |
| spelling | doaj-art-3851cf6a7b0e4dccb2e5d59bfbcb65552025-08-20T02:58:41ZengDe GruyterJournal of Laboratory Medicine2567-94302567-94492025-08-0149414915410.1515/labmed-2024-0160A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand diseaseBoulassel Mohamed-Rachid0Abdellatif Hussein1Al-Falahi Karima2Al-Hashmi Fatma3Bouchareb Yassine4Al-Abri Buthaina5Al-Jahdhami Habib6Department of Biomedical Science, College of Medicine and Health Sciences, Sultan Qaboos University, Seeb, OmanDepartment of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Seeb, OmanDepartment of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Seeb, OmanDepartment of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Seeb, OmanRadiology & Molecular Imaging, College of Medicine and Health Sciences, Sultan Qaboos University, Seeb, OmanDepartment of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Seeb, OmanDepartment of Biomedical Science, College of Medicine and Health Sciences, Sultan Qaboos University, Seeb, OmanA variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual aggregometry technique is the reference method, even having high inter-laboratory variability. The automated coagulation analyzers offer several advantages for routine testing. Herein the performance of the automated Sysmex CS2000/2100i analyzer was compared to the manual aggregometer Chrono-log 700 for assessing VWF:Co activity in patients suspected of having von Willebrand disease (VWD).https://doi.org/10.1515/labmed-2024-0160ristocetin co-factor activityvon willebrand diseaseautomation |
| spellingShingle | Boulassel Mohamed-Rachid Abdellatif Hussein Al-Falahi Karima Al-Hashmi Fatma Bouchareb Yassine Al-Abri Buthaina Al-Jahdhami Habib A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease Journal of Laboratory Medicine ristocetin co-factor activity von willebrand disease automation |
| title | A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease |
| title_full | A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease |
| title_fullStr | A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease |
| title_full_unstemmed | A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease |
| title_short | A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease |
| title_sort | comparative study between the chrono log 700 and the sysmex cs 2100i analyzers for assessing ristocetin cofactor activity in patients with von willebrand disease |
| topic | ristocetin co-factor activity von willebrand disease automation |
| url | https://doi.org/10.1515/labmed-2024-0160 |
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